Literature DB >> 6348033

Chloramphenicol acetyltransferase may confer resistance to fusidic acid by sequestering the drug.

G N Proctor, J McKell, R H Rownd.   

Abstract

Enterobacterial chloramphenicol acetyltransferase bound fusidic acid with high affinity, but did not acetylate the drug at an experimentally detectable rate. The enzyme may therefore confer resistance to fusidic acid by sequestering the drug and thereby preventing the drug from binding to translational elongation factor G.

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Year:  1983        PMID： 6348033      PMCID： PMC217776          DOI： 10.1128/jb.155.2.937-939.1983

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  11 in total

1.  Chloramphenicol acetyltransferase from chloramphenicol-resistant bacteria.

Authors:  W V Shaw
Journal:  Methods Enzymol       Date:  1975       Impact factor: 1.600

2.  Amplification of chloramphenicol resistance transposons carried by phage P1Cm in Escherichia coli.

Authors:  J Meyer; S Iida
Journal:  Mol Gen Genet       Date:  1979-10-03

3.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

4.  Affinity and hydrophobic chromatography of three variants of chloramphenicol acetyltransferases specified by R factors in Escherichia coli.

Authors:  Y Zaidenzaig; W V Shaw
Journal:  FEBS Lett       Date:  1976-03-01       Impact factor: 4.124

Review 5.  Plasmid-determined resistance to antimicrobial agents.

Authors:  J Davies; D I Smith
Journal:  Annu Rev Microbiol       Date:  1978       Impact factor: 15.500

6.  Plasmid-determined fusidic acid resistance in the Enterobacteriaceae.

Authors:  N Datta; R W Hedges; D Becker; J Davies
Journal:  J Gen Microbiol       Date:  1974-07

7.  Some properties of chloramphenicol acetyltransferase, with particular reference to the mechanism of inhibition by basic triphenylmethane dyes.

Authors:  H Tanaka; K Izaki; H Takahashi
Journal:  J Biochem       Date:  1974-11       Impact factor: 3.387

8.  Statistical analysis of enzyme kinetic data.

Authors:  W W Cleland
Journal:  Methods Enzymol       Date:  1979       Impact factor: 1.600

9.  Rosanilins: indicator dyes for chloramphenicol-resistant enterobacteria containing chloramphenicol acetyltransferase.

Authors:  G N Proctor; R H Rownd
Journal:  J Bacteriol       Date:  1982-06       Impact factor: 3.490

10.  Mapping of the resistance genes of the R plasmid NR1.

Authors:  T Miki; A M Easton; R H Rownd
Journal:  Mol Gen Genet       Date:  1978-01-17
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  7 in total

1.  Structural and functional characterization of three Type B and C chloramphenicol acetyltransferases from Vibrio species.

Authors:  Ashley Alcala; Guadalupe Ramirez; Allan Solis; Youngchang Kim; Kemin Tan; Oscar Luna; Karen Nguyen; Daniel Vazquez; Michael Ward; Min Zhou; Rory Mulligan; Natalia Maltseva; Misty L Kuhn
Journal:  Protein Sci       Date:  2019-12-06       Impact factor: 6.725

2.  Construction of an integration vector for use in the archaebacterium Methanococcus voltae and expression of a eubacterial resistance gene.

Authors:  P Gernhardt; O Possot; M Foglino; L Sibold; A Klein
Journal:  Mol Gen Genet       Date:  1990-04

Review 3.  Genetic and physical map of plasmid NR1: comparison with other IncFII antibiotic resistance plasmids.

Authors:  D D Womble; R H Rownd
Journal:  Microbiol Rev       Date:  1988-12

4.  The structural basis for substrate versatility of chloramphenicol acetyltransferase CATI.

Authors:  Tapan Biswas; Jacob L Houghton; Sylvie Garneau-Tsodikova; Oleg V Tsodikov
Journal:  Protein Sci       Date:  2012-03-06       Impact factor: 6.725

5.  Spirochaeta aurantia has diacetyl chloramphenicol esterase activity.

Authors:  C D Sohaskey; A G Barbour
Journal:  J Bacteriol       Date:  2000-04       Impact factor: 3.490

6.  Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops.

Authors:  Christopher A Elkins; Hiroshi Nikaido
Journal:  J Bacteriol       Date:  2002-12       Impact factor: 3.490

7.  Analysis of drug resistance in the archaebacterium Methanococcus voltae with respect to potential use in genetic engineering.

Authors:  O Possot; P Gernhardt; A Klein; L Sibold
Journal:  Appl Environ Microbiol       Date:  1988-03       Impact factor: 4.792
  7 in total

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