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Literature DB >> 6345713

Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution.

A Glazier, P J Tutschka, E R Farmer, G W Santos.

Abstract

Lethally irradiated rats treated with cyclosporin A (CsA) for 20-40 d develop classic graft-versus-host disease (GVHD) when reconstituted with syngeneic or autologous bone marrow, upon discontinuation of CsA, whereas normal rats do not. Syngeneic GVHD may be transferred to irradiated but not normal syngeneic recipients. Normal spleen cells fail to prevent the development or adoptive transfer of syngeneic GVHD.

Entities: Chemical Disease Species

Mesh：

Substances：
Cyclosporins

Year: 1983 PMID： 6345713 PMCID： PMC2187068 DOI： 10.1084/jem.158.1.1

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

13 in total

1. Biological effects of cyclosporin A: a new antilymphocytic agent.

Authors: J F Borel; C Feurer; H U Gubler; H Stähelin
Journal: Agents Actions Date: 1976-07

2. Graft-versus-host disease in recipients of syngeneic bone marrow.

Authors: E Gluckman; A Devergie; J Sohier; J H Saurat
Journal: Lancet Date: 1980-02-02 Impact factor: 79.321

3. Cyclosporin A and dexamethasone suppress T cell responses by selectively acting at distinct sites of the triggering process.

Authors: E L Larsson
Journal: J Immunol Date: 1980-06 Impact factor: 5.422

4. Use of cyclosporin A in allogeneic bone marrow transplantation in the rat.

Authors: P J Tutschka; W E Beschorner; A C Allison; W H Burns; G W Santos
Journal: Nature Date: 1979-07-12 Impact factor: 49.962

5. Effect of cyclosporin A on human lymphocyte responses in vitro. I. CsA allows for the expression of alloantigen-activated suppressor cells while preferentially inhibiting the induction of cytolytic effector lymphocytes in MLR.

Authors: A D Hess; P J Tutschka
Journal: J Immunol Date: 1980-06 Impact factor: 5.422

6. Effect of cyclosporin A on human lymphocyte responses in vitro. II. Induction of specific alloantigen unresponsiveness mediated by a nylon wool adherent suppressor cell.

Authors: A D Hess; P J Tutschka; G W Santos
Journal: J Immunol Date: 1981-03 Impact factor: 5.422

7. Cyclosporin-A-induced long-term survival of fully incompatible skin and heart grafts in rats.

Authors: D J White; K Rolles; T Ottawa; O Turell
Journal: Transplant Proc Date: 1980-06 Impact factor: 1.066

8. Skin grafts in rabbits with cyclosporin A: absence of induction of tolerance and untoward side effects.

Authors: A Gratwohl; I Forster; B Speck
Journal: Transplantation Date: 1981-02 Impact factor: 4.939

9. Prolongation of renal allograft survival in the rat by pretreatment with donor antigen and cyclosporin A.

Authors: W P Homan; K A Williams; P R Millard; P J Morris
Journal: Transplantation Date: 1981-06 Impact factor: 4.939

10. Suppressor cells in transplantation tolerance. I. Suppressor cells in the mechanism of tolerance in radiation chimeras.

Authors: P J Tutschka; A D Hess; W E Beschorner; G W Santos
Journal: Transplantation Date: 1981-09 Impact factor: 4.939

39 in total

Graft-versus-host disease in cyclosporin A-treated rats after syngeneic and autologous bone marrow reconstitution.

1. Biological effects of cyclosporin A: a new antilymphocytic agent.

2. Graft-versus-host disease in recipients of syngeneic bone marrow.

3. Cyclosporin A and dexamethasone suppress T cell responses by selectively acting at distinct sites of the triggering process.

4. Use of cyclosporin A in allogeneic bone marrow transplantation in the rat.

5. Effect of cyclosporin A on human lymphocyte responses in vitro. I. CsA allows for the expression of alloantigen-activated suppressor cells while preferentially inhibiting the induction of cytolytic effector lymphocytes in MLR.

6. Effect of cyclosporin A on human lymphocyte responses in vitro. II. Induction of specific alloantigen unresponsiveness mediated by a nylon wool adherent suppressor cell.

7. Cyclosporin-A-induced long-term survival of fully incompatible skin and heart grafts in rats.

8. Skin grafts in rabbits with cyclosporin A: absence of induction of tolerance and untoward side effects.

9. Prolongation of renal allograft survival in the rat by pretreatment with donor antigen and cyclosporin A.

10. Suppressor cells in transplantation tolerance. I. Suppressor cells in the mechanism of tolerance in radiation chimeras.

1. Effects of cyclosporin A on T-cell development in organ-cultured foetal thymus.

Review 2. Graft-versus-host disease of the intestine.

3. Cytometric analysis of DNA replication inhibited by emetine and cyclosporin A.

Review 4. Immunomodulation following chemotherapy.

Review 5. Autologous graft-versus-host disease.

6. Allogeneic and autologous bone-marrow transplantation.

7. Immunohistological skin alterations in allogeneic bone marrow transplantation.

8. Scleroderma renal crisis as a possible complication of cyclosporin A withdrawal.

9. Induction of self-reactive T cells after murine coronavirus infection.

Review 10. Autologous graft-versus-host disease: immunotherapy of breast cancer after bone marrow transplantation.