Literature DB >> 6340713

The effect of pre-injection of rat kidney F3 antigen on the development of passive Heymann nephritis.

J Cornish, A Z Barabas, R Lannigan.   

Abstract

The effect of repeated i.p. injections of a small dose of rat kidney F3 antigen, in an aqueous solution, on the development of passive Heymann nephritis in the rat has been investigated. The test animals receiving the antigen before the i.v. injection of the heterologous antibody developed more numerous and larger immune complexes on the epithelial side of the glomerular basement membrane than the control rats. It is suggested that the injected antigen is trapped in the glomerular basement membrane at sites where the pre-existing nephritogenic antigen is present making it possible for the more numerous and larger deposits to form.

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Year:  1983        PMID： 6340713      PMCID： PMC2040784     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  9 in total

1.  Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. V. Fixed glomerular antigens in the pathogenesis of heterologous immune complex glomerulonephritis.

Authors:  B J Van Damme; G J Fleuren; W W Bakker; R L Vernier; P J Hoedemaeker
Journal:  Lab Invest       Date:  1978-04       Impact factor: 5.662

2.  Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. I. The natural history: a histologic and immunohistologic study at the light microscopic and the ultrastructural level.

Authors:  K Feenstra; R van den Lee; H A Greben; A Arends; P J Hoedemaeker
Journal:  Lab Invest       Date:  1975-02       Impact factor: 5.662

3.  Induction of an autologous immune-complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody. I. Production of chronic progressive immune-complex glomerulonephritis.

Authors:  A Z Barabas; R Lannigan
Journal:  Br J Exp Pathol       Date:  1974-02

4.  Induction of an autologous immune complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody. II. Early glomerular lesions.

Authors:  A Z Barabas; R Lannigan
Journal:  Br J Exp Pathol       Date:  1974-06

5.  Antibodies against the mitochondrial fraction of liver after toxic liver damage in rats.

Authors:  R N Pinckard; D M Weir
Journal:  Clin Exp Immunol       Date:  1966-01       Impact factor: 4.330

6.  Chronic nephritis induced by antibodies reacting with glomerular-bound immune complexes.

Authors:  L A van Es; A P Blok; L Schoenfield; R J Glassock
Journal:  Kidney Int       Date:  1977-02       Impact factor: 10.612

7.  Experimental glomerulonephritis in the isolated perfused rat kidney.

Authors:  W G Couser; D R Steinmuller; M M Stilmant; D J Salant; L M Lowenstein
Journal:  J Clin Invest       Date:  1978-12       Impact factor: 14.808

8.  Passive Heymann's nephritis as a model of immune glomerulonephritis mediated by antibodies to immunoglobulins.

Authors:  M Zanetti; P Druet
Journal:  Clin Exp Immunol       Date:  1980-08       Impact factor: 4.330

9.  Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. IV. Investigations into the pathogenesis of the model.

Authors:  G J Fleuren; R vd Lee; H A Greben; B J Van Damme; P J Hoedemaeker
Journal:  Lab Invest       Date:  1978-04       Impact factor: 5.662
  9 in total
  2 in total

1.  Stimulation of circulating autoantibody levels in the rat with established progressive passive Heymann nephritis.

Authors:  A Z Barabas; J Cornish; R Lannigan
Journal:  Clin Exp Immunol       Date:  1986-07       Impact factor: 4.330

2.  Passive Heymann-like nephritis in the rabbit.

Authors:  A Z Barabas; J Cornish; R Lannigan
Journal:  Br J Exp Pathol       Date:  1985-06
  2 in total

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