Literature DB >> 6339459

Synthesis and antibacterial activity of 6- and 7-[2-(5-carboxyimidazole-4-carboxamido)phenylacetamido]-penicillins and cephalosporins.

N Yasuda, H Iwagami, E Nakanishi, T Nakamiya, Y Sasaki, T Murata.   

Abstract

The synthesis and antibacterial activity of a series of beta-lactam antibiotics having a 5-carboxyimidazole-4-carbonyl group attached through an amide linkage to ampicillin, cephaloglycin or their analogs are described. Some compounds of this series were found to possess high activity against Pseudomonas and other Gram-negative bacteria.

Entities:  

Mesh:

Substances:

Year:  1983        PMID: 6339459     DOI: 10.7164/antibiotics.36.242

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  5 in total

1.  Pharmacokinetics of cefpimizole in normal humans after single- and multiple-dose intravenous infusions.

Authors:  D B Lakings; J M Friis; R J Brown; H R Allen
Journal:  Antimicrob Agents Chemother       Date:  1984-12       Impact factor: 5.191

2.  Tolerance and disposition of cefpimizole in normal human volunteers after intramuscular administration.

Authors:  E Novak; D B Lakings; L M Paxton
Journal:  Antimicrob Agents Chemother       Date:  1987-11       Impact factor: 5.191

3.  In vitro comparative antimicrobial activity of cefpimizole against clinical isolates from five medical centers.

Authors:  R N Jones; L W Ayers; T L Gavan; E H Gerlach; H M Sommers
Journal:  Antimicrob Agents Chemother       Date:  1985-06       Impact factor: 5.191

4.  Pharmacokinetics and dose proportionality of cefpimizole in normal humans after intramuscular administration.

Authors:  D B Lakings; E Novak; J M Friis; C M Lunan; L M Paxton
Journal:  Antimicrob Agents Chemother       Date:  1986-02       Impact factor: 5.191

5.  Synthesis and evaluation of imidazole-4,5- and pyrazine-2,3-dicarboxamides targeting dengue and yellow fever virus.

Authors:  Milind Saudi; Joanna Zmurko; Suzanne Kaptein; Jef Rozenski; Johan Neyts; Arthur Van Aerschot
Journal:  Eur J Med Chem       Date:  2014-09-22       Impact factor: 6.514

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.