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Literature DB >> 4026275

In vitro comparative antimicrobial activity of cefpimizole against clinical isolates from five medical centers.

R N Jones, L W Ayers, T L Gavan, E H Gerlach, H M Sommers.

Abstract

Cefpimizole was compared with cefoperazone and cefotaxime against 6,599 clinical bacterial isolates from five medical centers. Cefoperazone and cefotaxime were both more active and provided a greater spectrum of antimicrobial coverage than cefpimizole. Some of the cefpimizole minimum concentrations inhibiting 50% of tested strains were as follows: Citrobacter freundii and Enterobacter cloacae, 16 micrograms/ml; Escherichia coli and Klebsiella pneumoniae, 2.0 micrograms/ml; Proteus mirabilis, 1.0 microgram/ml; Pseudomonas aeruginosa, 16 micrograms/ml; Staphylococcus spp., 32 micrograms/ml; and the enterococci, greater than 32 micrograms/ml.

Entities: Chemical Species

Mesh：

Substances：

Year: 1985 PMID： 4026275 PMCID： PMC180204 DOI： 10.1128/AAC.27.6.982

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

8 in total

1. In vitro antimicrobial susceptibility testing using 30 microG and 75 microG U63196-E (cefpimizole AC-1370) disks.

Authors: R N Jones; C Thornsberry; A L Barry
Journal: Diagn Microbiol Infect Dis Date: 1985-01 Impact factor: 2.803

2. Synthesis and antibacterial activity of 6- and 7-[2-(5-carboxyimidazole-4-carboxamido)phenylacetamido]-penicillins and cephalosporins.

Authors: N Yasuda; H Iwagami; E Nakanishi; T Nakamiya; Y Sasaki; T Murata
Journal: J Antibiot (Tokyo) Date: 1983-03 Impact factor: 2.649

3. In vitro activity and beta-lactamase stability of U-63196E, a novel cephalosporin.

Authors: H C Neu; P Labthavikul
Journal: Antimicrob Agents Chemother Date: 1983-09 Impact factor: 5.191

4. In vitro evaluation of U63196-E (AC-1370): antimicrobial activity, beta-lactamase stability, and beta-lactamase inhibition.

Authors: R N Jones
Journal: Diagn Microbiol Infect Dis Date: 1984-04 Impact factor: 2.803

1 in total

1. Penetration of cefazolin, ceftriaxone, cefoperazone, and ceftazidime into human gallbladder tissue and bile.

Authors: S A Berger; Y Levy; A Halevy; A Gorea; R Orda
Journal: World J Surg Date: 1988-10 Impact factor: 3.352

1 in total

In vitro comparative antimicrobial activity of cefpimizole against clinical isolates from five medical centers.

1. In vitro antimicrobial susceptibility testing using 30 microG and 75 microG U63196-E (cefpimizole AC-1370) disks.

2. Synthesis and antibacterial activity of 6- and 7-[2-(5-carboxyimidazole-4-carboxamido)phenylacetamido]-penicillins and cephalosporins.

3. In vitro activity and beta-lactamase stability of U-63196E, a novel cephalosporin.

4. In vitro evaluation of U63196-E (AC-1370): antimicrobial activity, beta-lactamase stability, and beta-lactamase inhibition.

5. Effects of AC-1370, a new semisynthetic cephalosporin, on phagocyte functions.

6. Antibacterial activities of SM-1652 compared with those of other broad-spectrum cephalosporins.

7. Pharmacokinetics of cefpimizole in normal humans after single- and multiple-dose intravenous infusions.

Review 8. Infectious diseases of the thyroid gland.

1. Penetration of cefazolin, ceftriaxone, cefoperazone, and ceftazidime into human gallbladder tissue and bile.