Literature DB >> 6337208

Production of monoclonal antibodies to hepatitis B surface and core antigens, and use in the detection of viral antigens in liver biopsies.

R S Tedder, P Guarascio, J L Yao, R B Lord, A L Eddleston.   

Abstract

Hybridomas secreting monoclonal antibodies to HBsAg and HBcAg were prepared from immunized mice. An antibody capture radioimmunoassay was used to detect and select appropriate hybrids for propagation and cloning. The advantages of this assay were discussed. The resulting monoclonal antibodies were compared with conventional polyclonal antisera for the detection of virus antigens in liver tissue and found to give excellent results.

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Year:  1983        PMID： 6337208      PMCID： PMC2134181          DOI： 10.1017/s0022172400063932

Source DB:  PubMed          Journal:  J Hyg (Lond)        ISSN： 0022-1724


  13 in total

1.  Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors:  G Köhler; C Milstein
Journal:  Nature       Date:  1975-08-07       Impact factor: 49.962

2.  Hepatitis B core and surface antigens in liver tissue. Light and electron microscopic localization by the peroxidase-labeled antibody method.

Authors:  G Yamada; P K Nakane
Journal:  Lab Invest       Date:  1977-06       Impact factor: 5.662

3.  Pattern of core and surface expression in liver tissue reflects state of specific immune response in hepatitis B.

Authors:  F Gudat; L Bianchi; W Sonnabend; G Thiel; W Aenishaenslin; G A Stalder
Journal:  Lab Invest       Date:  1975-01       Impact factor: 5.662

4.  Distribution patterns of hepatitis B surface antigen (HBsAg) in the liver of hepatitis patients.

Authors:  M B Ray; V J Desmet; J Fevery; J De Groote; A F Bradburne; J Desmyter
Journal:  J Clin Pathol       Date:  1976-02       Impact factor: 3.411

5.  Immunopathological aspects of hepatitis type B.

Authors:  A Nowoslawski; K Krawczynski; T Nazarewicz; J Slusarczyk
Journal:  Am J Med Sci       Date:  1975 Sep-Oct       Impact factor: 2.378

6.  The production of monoclonal antibodies to rubella haemagglutinin and their use in antibody-capture assays for rubella-specific IgM.

Authors:  R S Tedder; J L Yao; M J Anderson
Journal:  J Hyg (Lond)       Date:  1982-04

7.  Use of an enzyme-linked immunosorbent assay for screening hybridoma antibodies against hepatitis B surface antigen.

Authors:  A Boniolo; M Dovis; R Matteja
Journal:  J Immunol Methods       Date:  1982       Impact factor: 2.303

8.  Analysis of antigenic drift in the haemagglutinin molecule of influenza B virus with monoclonal antibodies.

Authors:  R G Webster; M T Berton
Journal:  J Gen Virol       Date:  1981-06       Impact factor: 3.891

9.  Immunofluorescent detection of hepatitis B antigen in paraffin-embedded liver tissue.

Authors:  M B Ray; V J Desmet
Journal:  J Immunol Methods       Date:  1975-01       Impact factor: 2.303

10.  Contrasting patterns and frequency of antibodies to the surface, core, and e antigens of hepatitis B virus in blood donors and in homosexual patients.

Authors:  R S Tedder; C H Cameron; R Wilson-Croome; D R Howell; A Colgrove; J A Barbara
Journal:  J Med Virol       Date:  1981       Impact factor: 2.327
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  9 in total

1.  Monoclonal 'internal image' anti-idiotypic antibodies of hepatitis B surface antigen.

Authors:  Y M Thanavala; A Bond; R Tedder; F C Hay; I M Roitt
Journal:  Immunology       Date:  1985-06       Impact factor: 7.397

2.  Novel mechanism of antibodies to hepatitis B virus in blocking viral particle release from cells.

Authors:  Avidan U Neumann; Sandra Phillips; Idit Levine; Samreen Ijaz; Harel Dahari; Rachel Eren; Shlomo Dagan; Nikolai V Naoumov
Journal:  Hepatology       Date:  2010-09       Impact factor: 17.425

3.  In-vitro cell-mediated cytotoxicity for autologous liver cells in chronic non-A, non-B hepatitis.

Authors:  M Mondelli; A Alberti; F Tremolada; R Williams; A L Eddleston; G Realdi
Journal:  Clin Exp Immunol       Date:  1986-01       Impact factor: 4.330

4.  Widespread presence of cytoplasmic HBcAg in hepatitis B infected liver detected by improved immunochemical methods.

Authors:  E J Gowans; C J Burrell
Journal:  J Clin Pathol       Date:  1985-04       Impact factor: 3.411

5.  Definition of hepatitis B virus (HBV)-specific target antigens recognized by cytotoxic T cells in acute HBV infection.

Authors:  M U Mondelli; F Bortolotti; P Pontisso; E G Rondanelli; R Williams; G Realdi; A Alberti; A L Eddleston
Journal:  Clin Exp Immunol       Date:  1987-05       Impact factor: 4.330

6.  Recognition of several idiotopes on a monoclonal anti-hepatitis B virus surface antigen using monoclonal anti-idiotypic antibodies.

Authors:  Y M Thanavala; M J Moore; R Tedder; F C Hay; I M Roitt
Journal:  Immunology       Date:  1988-04       Impact factor: 7.397

7.  Molecular mimicry of hepatitis B surface antigen by an anti-idiotype-derived synthetic peptide.

Authors:  M W Pride; H Shi; J M Anchin; D S Linthicum; P T LoVerde; A Thakur; Y Thanavala
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205

8.  A surrogate hepatitis B virus antigenic epitope represented by a synthetic peptide and an internal image antiidiotype antibody.

Authors:  Y M Thanavala; S E Brown; C R Howard; I M Roitt; M W Steward
Journal:  J Exp Med       Date:  1986-07-01       Impact factor: 14.307

9.  Mimicry of the a determinant of hepatitis B surface antigen by an antiidiotypic antibody. I. Evaluation in hepatitis B surface antigen responder and nonresponder strains.

Authors:  M W Pride; A Thakur; Y Thanavala
Journal:  J Exp Med       Date:  1993-01-01       Impact factor: 14.307
  9 in total

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