Literature DB >> 63370

Quinidine syncope: torsade de pointes with low quinidine plasma concentrations.

H R Jenzer, F Hagemeijer.   

Abstract

In 2 patients without clinically significant ischemic heart diseases, oral quinidine was used to control supraventricular arrhythmias. In both patients, syncopal attacks occurred, caused by a particular type of ventricular tachyarrhythmia called torsades de pointes. Quinidine plasma concentrations were low (2.6 and 1.2 mg/1, respectively); QRS duration was normal, but the Q-T interval was markedly prolonged.

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Year:  1976        PMID: 63370

Source DB:  PubMed          Journal:  Eur J Cardiol        ISSN: 0301-4711


  13 in total

Review 1.  Drug-induced long QT syndrome.

Authors:  Prince Kannankeril; Dan M Roden; Dawood Darbar
Journal:  Pharmacol Rev       Date:  2010-12       Impact factor: 25.468

Review 2.  A prolonged QTc interval. Is it an important effect of antiarrhythmic drugs?

Authors:  F A Fish; D M Roden
Journal:  Med Toxicol Adverse Drug Exp       Date:  1989 Nov-Dec

Review 3.  Update on the evaluation of a new drug for effects on cardiac repolarization in humans: issues in early drug development.

Authors:  Vaibhav Salvi; Dilip R Karnad; Gopi Krishna Panicker; Snehal Kothari
Journal:  Br J Pharmacol       Date:  2009-09-23       Impact factor: 8.739

4.  Facts, fancies and follies of drug-induced QT/QTc interval shortening.

Authors:  Marek Malik
Journal:  Br J Pharmacol       Date:  2010-01       Impact factor: 8.739

5.  "Torsade de pointes" tachycardia. Re-entry or focal activity?

Authors:  C N D'Alnoncourt; W Zierhut; B Blüderitz
Journal:  Br Heart J       Date:  1982-09

6.  Torsade de pointes.

Authors:  S K Agarwal
Journal:  J Natl Med Assoc       Date:  1981-10       Impact factor: 1.798

7.  Magnesium therapy for intractable ventricular tachyarrhythmias in normomagnesemic patients.

Authors:  L T Iseri; P Chung; J Tobis
Journal:  West J Med       Date:  1983-06

Review 8.  QT-interval prolonging drugs: mechanisms and clinical relevance of their arrhythmogenic hazards.

Authors:  M Zehender; S Hohnloser; H Just
Journal:  Cardiovasc Drugs Ther       Date:  1991-04       Impact factor: 3.727

9.  H2-receptor antagonism is not pro-arrhythmic in a chronic canine model.

Authors:  A C Uprichard; D W Harron
Journal:  Basic Res Cardiol       Date:  1990 Sep-Oct       Impact factor: 17.165

10.  Torsades de pointes, a common arrhythmia, induced by medication.

Authors:  P T Ko; S Gulamhusein; W J Kostuk; G J Klein
Journal:  Can Med Assoc J       Date:  1982-09-01       Impact factor: 8.262

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