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Literature DB >> 7104914

Torsades de pointes, a common arrhythmia, induced by medication.

P T Ko, S Gulamhusein, W J Kostuk, G J Klein.

Abstract

Between May 1980 and April 1981 four patients were referred to one hospital with syncope or recurrent ventricular fibrillation while taking antiarrhythmic or phenothiazine drugs. In all the patients ventricular tachyarrhythmias with the characteristics of torsades de pointes were documented in association with prolonged QT intervals. With removal of the offending agent (in all the patients) supplemented by temporary overdrive pacing (in two patients) the tachyarrhythmias subsided. This study suggests that drug-induced torsades de pointes is an important clinical entity that occurs more frequently than has been suspected.

Entities: Chemical Disease Species

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Year: 1982 PMID： 7104914 PMCID： PMC1862015

Source DB: PubMed Journal: Can Med Assoc J ISSN： 0008-4409 Impact factor: 8.262

19 in total

Torsades de pointes, a common arrhythmia, induced by medication.

1. Torsade De Pointes, an atypical ventricular tachycardia.

2. The long Q-T syndrome.

3. Electrocardiographic changes and cardiac arrhythmias in patients receiving psychotropic drugs.

4. [Ventricular tachycardia with 2 variable opposing foci].

5. Early and late results of conversion of atrial fibrillation with quinidine. A clinical and hemodynamic study.

6. [The syndrome, "QT lengthening and syncope due to torsion of the points"].

7. [The long QT syndrome and syncope caused by spike torsades].

8. Quinidine-induced ventricular flutter and fibrillation without digitalis therapy.

9. Quinidine-induced recurrent ventricular fibrillation: (quinidine syncope) treated with transvenous pacemaker.

10. Thioridazine (mellaril)-induced ventricular tachycardia controlled with an artificial pacemaker.

Review 1. Proarrhythmic risk with antipsychotic and antidepressant drugs: implications in the elderly.

2. Sotalol, hypokalaemia, syncope, and torsade de pointes.