Literature DB >> 6334624

Interaction of HLA and immunoglobulin antigens in type 1 (insulin-dependent) diabetes.

L L Field, C E Anderson, K Neiswanger, S E Hodge, M A Spence, J I Rotter.   

Abstract

We analyzed 88 unrelated subjects with Type 1 (insulin-dependent) diabetes and 64 sibling controls (maximum one per diabetic) for associations between immunoglobulin allotype antigens (GM and KM) and Type 1 diabetes. None were found. However, we did find interactions between GM, HLA-DR, and Type 1 diabetes (significant or of borderline significance after considering the effect of multiple tests): possession of Glm(2) appeared to increase susceptibility to diabetes in individuals who had HLA-DR3 but not HLA-DR4, while possession of G3m(5) appeared to increase susceptibility in individuals who had HLA-DR4 but not HLA-DR3. These results suggest that genetic predisposition to Type 1 diabetes is partially determined by alleles at the GM locus (or a locus in linkage disequilibrium with GM) interacting with alleles at the HLA-DR locus (or a locus in linkage disequilibrium with HLA-DR).

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Year:  1984        PMID： 6334624     DOI： 10.1007/bf00290384

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  25 in total

Review 1.  Role of MHC gene products in immune regulation.

Authors:  B Benacerraf
Journal:  Science       Date:  1981-06-12       Impact factor: 47.728

2.  Heterogeneity of insulin-dependent diabetes-new evidence.

Authors:  T S Dunsworth; S S Rich; N E Morton; J Barbosa
Journal:  Clin Genet       Date:  1982-04       Impact factor: 4.438

3.  Immunoglobulin allotypes and immune response to meningococcal group B polysaccharide.

Authors:  J P Pandey; W D Zollinger; H H Fudenberg; C B Loadholt
Journal:  J Clin Invest       Date:  1981-11       Impact factor: 14.808

4.  Association between an HLA haplotype and low responsiveness to tetanus toxoid in man.

Authors:  T Sasazuki; Y Kohno; I Iwamoto; M Tanimura; S Naito
Journal:  Nature       Date:  1978-03-23       Impact factor: 49.962

5.  Some epistatic two-locus models of disease. II. The confounding of linkage and association.

Authors:  S E Hodge; M A Spence
Journal:  Am J Hum Genet       Date:  1981-05       Impact factor: 11.025

6.  Epistasis effect: an alternative to the hypothesis of linkage disequilibrium in HLA associated diseases.

Authors:  F Clerget-Darpoux; C Bonaïti-Pellié
Journal:  Ann Hum Genet       Date:  1980-10       Impact factor: 1.670

7.  Close genetic linkage between diabetes mellitus and kidd blood group.

Authors:  S E Hodge; C E Anderson; K Neiswanger; L L Field; M A Spence; R S Sparkes; M C Sparkes; M Crist; P I Terasaki; D L Rimoin; J I Rotter
Journal:  Lancet       Date:  1981-10-24       Impact factor: 79.321

8.  Association between immunoglobulin allotypes and immune responses to Haemophilus influenzae and Meningococcus polysaccharides.

Authors:  J P Pandey; H H Fudenberg; G Virella; C U Kyong; C B Loadholt; R M Galbraith; E C Gotschlich; J C Parke
Journal:  Lancet       Date:  1979-01-27       Impact factor: 79.321

9.  Immunoglobulin allotypes and response to tetanus toxoid in Papua, New Guinea.

Authors:  M S Schanfield; J V Wells; H H Fudenberg
Journal:  J Immunogenet       Date:  1979-10

10.  HLA genotypic study of insulin-dependent diabetes the excess of DR3/DR4 heterozygotes allows rejection of the recessive hypothesis.

Authors:  J I Rotter; C E Anderson; R Rubin; J E Congleton; P I Terasaki; D L Rimoin
Journal:  Diabetes       Date:  1983-02       Impact factor: 9.461
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  8 in total

Review 1.  The genetics of type I (insulin dependent) diabetes mellitus.

Authors:  D Cavan; S Bain; A Barnett
Journal:  J Med Genet       Date:  1992-07       Impact factor: 6.318

2.  Interaction between T cell receptor beta chain and immunoglobulin heavy chain region genes in susceptibility to insulin-dependent diabetes mellitus.

Authors:  L L Field; D K Stephure; R G McArthur
Journal:  Am J Hum Genet       Date:  1991-09       Impact factor: 11.025

Review 3.  Genetics of autoimmune endocrine diseases.

Authors:  J F Bach; S Caillat-Zucman
Journal:  Springer Semin Immunopathol       Date:  1993

4.  The immunoglobulin heavy-chain variable region in insulin-dependent diabetes mellitus: affected-sib-pair analysis and association studies.

Authors:  R Veijola; M Knip; R Puukka; H Reijonen; D W Cox; J Ilonen
Journal:  Am J Hum Genet       Date:  1996-08       Impact factor: 11.025

5.  HLA-dependent GM effects in insulin-dependent diabetes: evidence from pairs of affected siblings.

Authors:  L L Field; M H Dizier; C E Anderson; M A Spence; J I Rotter
Journal:  Am J Hum Genet       Date:  1986-11       Impact factor: 11.025

6.  Shared genetic susceptibility of type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus: contributions of HLA and haptoglobin.

Authors:  S S Rich; S S Panter; F C Goetz; B Hedlund; J Barbosa
Journal:  Diabetologia       Date:  1991-05       Impact factor: 10.122

7.  A T cell receptor beta chain polymorphism is associated with patients developing insulin-dependent diabetes after the age of 20 years.

Authors:  S A McMillan; C A Graham; P J Hart; D R Hadden; T A McNeill
Journal:  Clin Exp Immunol       Date:  1990-12       Impact factor: 4.330

8.  A combined segregation and linkage analysis of insulin-dependent diabetes mellitus.

Authors:  S S Rich; A Green; N E Morton; J Barbosa
Journal:  Am J Hum Genet       Date:  1987-03       Impact factor: 11.025
  8 in total

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