Literature DB >> 6333369

Leucocyte adherence inhibition assay for cell-mediated immunity and immunodiagnosis of pancreatic cancer.

M Onji.   

Abstract

The present study was conducted to determine whether the leucocyte adherence inhibition (LAI) assay was dependent on cell-mediated immunity and whether it was of potential use in diagnosis of pancreatic cancer. The LAI response was significantly positive in 15 PPD skin-test positive individuals but it was abated by pretreatment of sensitized mononuclear cells with anti-T cell antibody (OKT3) or by depletion of monocytes. Therefore, the LAI assay is probably related to cell-mediated immunity. The LAI assay was positive in 13 of 16 patients with pancreatic cancer using pancreatic cancer extract; however, a positive reaction was not found in 11 cases of chronic pancreatitis and 10 cases of hepatocellular carcinoma. Thus, the LAI assay appears rather specific. Mononuclear cells of pancreatic and gastric cancer patients showed LAI reactivity to autologous tumor extracts.

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Year:  1984        PMID： 6333369     DOI： 10.1007/bf02779122

Source DB:  PubMed          Journal:  Gastroenterol Jpn        ISSN： 0435-1339


  9 in total

1.  The L.A.I. microtest: a rapid and sensitive precedure for the demonstration of cell-mediated immunity in vitro.

Authors:  P G Holt; L M Roberts; P J Fimmel; D Keast
Journal:  J Immunol Methods       Date:  1975-09       Impact factor: 2.303

2.  The role of leukocyte subpopulations in the indirect leukocyte adherence inhibition assay in the mammary tumor virus system.

Authors:  P Creemers
Journal:  Eur J Immunol       Date:  1977-01       Impact factor: 5.532

3.  Leukocyte adherence inhibition: a simple test for cell-mediated tumour immunity and serum blocking factors.

Authors:  W J Halliday; S Miller
Journal:  Int J Cancer       Date:  1972-05-15       Impact factor: 7.396

4.  A leukocyte adherence inhibition test for cell-mediated immunity.

Authors:  F Lampert; E Dietmair
Journal:  Klin Wochenschr       Date:  1973-02-15

5.  Leukocyte adherence inhibition by soluble tumor antigens in breast cancer patients.

Authors:  T Fujisawa; S R Waldman; R H Yonemoto
Journal:  Cancer       Date:  1977-02       Impact factor: 6.860

6.  Leucocyte adherence inhibition for detecting specific tumour immunity in early pancreatic cancer.

Authors:  D N Tataryn; J K MacFarlane; D M Thomson
Journal:  Lancet       Date:  1978-05-13       Impact factor: 79.321

7.  Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express Ia-like antigens.

Authors:  R L Evans; T J Faldetta; R E Humphreys; D M Pratt; E J Yunis; S F Schlossman
Journal:  J Exp Med       Date:  1978-11-01       Impact factor: 14.307

8.  Peripheral blood Ia-positive T cells. Increases in certain diseases and after immunization.

Authors:  D T Yu; R J Winchester; S M Fu; A Gibofsky; H S Ko; H G Kunkel
Journal:  J Exp Med       Date:  1980-01-01       Impact factor: 14.307

9.  Ia determinants on stimulated human T lymphocytes. Occurrence on mitogen- and antigen-activated T cells.

Authors:  H S Ko; S M Fu; R J Winchester; D T Yu; H G Kunkel
Journal:  J Exp Med       Date:  1979-08-01       Impact factor: 14.307
  9 in total
  2 in total

1.  Leucocyte adherence inhibition assay for immunodiagnosis of hepatocellular carcinoma.

Authors:  M Onji
Journal:  Gastroenterol Jpn       Date:  1984-08

2.  Measurement by leukocyte adherence inhibition of autosensitization of cancer patients to myelin basic protein.

Authors:  Z Gouda; D M Thomson
Journal:  Jpn J Cancer Res       Date:  1988-04
  2 in total

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