Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Effect of pore structure on energy barriers and applied voltage profiles. II. Unsymmetrical channels.

Literature DB >> 6331540

Effect of pore structure on energy barriers and applied voltage profiles. II. Unsymmetrical channels.

Abstract

This paper examines "realistic" pores, i.e., ones that are neither symmetric nor of uniform diameter. Methods are described that permit estimation of the image potential for an ion in an aqueous pore spanning a lipid membrane and for the electric field produced in such a pore when a transmembrane potential is applied. They are used to model features of the delayed rectifier potassium channel. Constraints on the geometry of the exterior mouth, the dielectric properties of the narrow part of the pore and the conduction mechanism are determined for this channel.

Entities: Chemical

Mesh：

Substances：
Ion Channels
Potassium

Year: 1984 PMID： 6331540 PMCID： PMC1435004 DOI： 10.1016/s0006-3495(84)84258-7

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

26 in total

6. Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel.

Authors: A Tinker; A R Lindsay; A J Williams
Journal: Biophys J Date: 1992-05 Impact factor: 4.033

7. Aminoglycoside blockade of Ca2(+)-activated K+ channel from rat brain synaptosomal membranes incorporated into planar bilayers.

Authors: K Nomura; K Naruse; K Watanabe; M Sokabe
Journal: J Membr Biol Date: 1990-05 Impact factor: 1.843

8. An ion's view of the potassium channel. The structure of the permeation pathway as sensed by a variety of blocking ions.

Authors: R J French; J J Shoukimas
Journal: J Gen Physiol Date: 1985-05 Impact factor: 4.086

8 in total

Effect of pore structure on energy barriers and applied voltage profiles. II. Unsymmetrical channels.

1. Ionic selectivity of Na and K channels of nerve membranes.

2. Ion-membrane interactions as structural forces.

3. Diffusion-limited ion flow through pores.

4. Dielectric behaviour of dry synthetic polypeptides.

5. Energy barriers for passage of ions through channels. Exact solution of two electrostatic problems.

6. Single channel recordings of K+ currents in squid axons.

7. Helical channels in crystals of gramicidin A and of a cesium--gramicidin A complex: an x-ray diffraction study.

8. Blockage of squid axon potassium conductance by internal tetra-N-alkylammonium ions of various sizes.

9. Potassium channels as multi-ion single-file pores.

10. Electrostatic calculations for an ion channel. I. Energy and potential profiles and interactions between ions.

1. Electrostatic influence on ion transport through the alphaHL channel.

Review 2. Ion conduction and discrimination in the sarcoplasmic reticulum ryanodine receptor/calcium-release channel.

3. Energy barrier presented to ions by the vestibule of the biological membrane channel.

4. Structural aspects of the sarcoplasmic reticulum K+ channel revealed by gallamine block.

5. Lanthanides Report Calcium Sensor in the Vestibule of Ryanodine Receptor.

6. Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel.

7. Aminoglycoside blockade of Ca2(+)-activated K+ channel from rat brain synaptosomal membranes incorporated into planar bilayers.

8. An ion's view of the potassium channel. The structure of the permeation pathway as sensed by a variety of blocking ions.