Literature DB >> 6330695

DNA sequence of the 5' flanking region of the human interleukin 2 gene: homologies with adult T-cell leukemia virus.

N J Holbrook, M Lieber, G R Crabtree.   

Abstract

We previously reported the sequence of the gene for human interleukin 2 (IL-2) which included about 220 b.p. of the 5' flanking region. In this report we have extended the 5' sequence to 1263 b.p. before the start site of transcription and have compared the entire sequence of the IL-2 gene and its 5' flanking region with that of Adult T-cell leukemia virus (ATLV). Four regions of limited homology were noted. Three areas of homology to the viral long terminal repeat (LTR) were seen in the 5' sequence flanking IL-2. A fourth region of homology to the viral LTR was located within the second intron of the IL-2 gene. While the significance of these homologies is not known, it is possible that they are involved in regulating the expression of ATLV and IL-2, both of which are generally restricted to T cells.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6330695      PMCID： PMC318895          DOI： 10.1093/nar/12.12.5005

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  15 in total

1.  Selective in vitro growth of T lymphocytes from normal human bone marrows.

Authors:  D A Morgan; F W Ruscetti; R Gallo
Journal:  Science       Date:  1976-09-10       Impact factor: 47.728

2.  Computer analysis of nucleic acids and proteins.

Authors:  C L Queen; L J Korn
Journal:  Methods Enzymol       Date:  1980       Impact factor: 1.600

3.  Heterogeneity of human T-cell growth factor(s) due to variable glycosylation.

Authors:  R J Robb; K A Smith
Journal:  Mol Immunol       Date:  1981-12       Impact factor: 4.407

4.  Enhanced graphic matrix analysis of nucleic acid and protein sequences.

Authors:  J V Maizel; R P Lenk
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

5.  Partial nucleotide sequence of the 300-nucleotide interspersed repeated human DNA sequences.

Authors:  C M Rubin; C M Houck; P L Deininger; T Friedmann; C W Schmid
Journal:  Nature       Date:  1980-03-27       Impact factor: 49.962

Review 6.  T-cell growth factor.

Authors:  K A Smith
Journal:  Immunol Rev       Date:  1980       Impact factor: 12.988

7.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

8.  Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.

Authors:  B J Poiesz; F W Ruscetti; A F Gazdar; P A Bunn; J D Minna; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

9.  Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line.

Authors:  S Gillis; J Watson
Journal:  J Exp Med       Date:  1980-12-01       Impact factor: 14.307

10.  T cell growth factor receptors. Quantitation, specificity, and biological relevance.

Authors:  R J Robb; A Munck; K A Smith
Journal:  J Exp Med       Date:  1981-11-01       Impact factor: 14.307
View more
  8 in total

1.  cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

Authors:  C B Thompson; C Y Wang; I C Ho; P R Bohjanen; B Petryniak; C H June; S Miesfeldt; L Zhang; G J Nabel; B Karpinski
Journal:  Mol Cell Biol       Date:  1992-03       Impact factor: 4.272

2.  Identification of new gene products coded from X regions of human T-cell leukemia viruses.

Authors:  K Shimotohno; M Miwa; D J Slamon; I S Chen; H Hoshino; M Takano; M Fujino; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

3.  Regulatory anatomy of the murine interleukin-2 gene.

Authors:  T J Novak; P M White; E V Rothenberg
Journal:  Nucleic Acids Res       Date:  1990-08-11       Impact factor: 16.971

4.  Distinct H-2-linked regulation of T-cell responses to the pre-S and S regions of the same hepatitis B surface antigen polypeptide allows circumvention of nonresponsiveness to the S region.

Authors:  D R Milich; M K McNamara; A McLachlan; G B Thornton; F V Chisari
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

5.  A viral long terminal repeat in the interleukin 2 gene of a cell line that constitutively produces interleukin 2.

Authors:  S J Chen; N J Holbrook; K F Mitchell; C A Vallone; J S Greengard; G R Crabtree; Y Lin
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

6.  Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells.

Authors:  U Siebenlist; D B Durand; P Bressler; N J Holbrook; C A Norris; M Kamoun; J A Kant; G R Crabtree
Journal:  Mol Cell Biol       Date:  1986-09       Impact factor: 4.272

7.  Regulation of expression of the human interferon gamma gene.

Authors:  K J Hardy; B M Peterlin; R E Atchison; J D Stobo
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

8.  The effect of immunosuppressive agents on the induction of nuclear factors that bind to sites on the interleukin 2 promoter.

Authors:  A Granelli-Piperno; P Nolan; K Inaba; R M Steinman
Journal:  J Exp Med       Date:  1990-12-01       Impact factor: 14.307
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.