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Literature DB >> 6330360

Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones.

Abstract

A series of novel triazol-3-ones have been synthesized, and their in vitro and in vivo antifungal properties are reported. Compound 68 (itraconazole), which displays a pronounced oral activity against vaginal candidosis in rats and against microsporosis in guinea pigs, has been selected for clinical evaluation.

Entities: Chemical Disease Species

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Year: 1984 PMID： 6330360 DOI： 10.1021/jm00373a015

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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Cited

17 in total

1. Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling.

Authors: Wei Shi; Benjamin A Nacev; Blake T Aftab; Sarah Head; Charles M Rudin; Jun O Liu
Journal: J Med Chem Date: 2011-10-05 Impact factor: 7.446

2. In vitro susceptibilities of isolates of Sporothrix schenckii to itraconazole and terbinafine.

Authors: Lidiane Meire Kohler; Paulo César Fialho Monteiro; Rosane Christine Hahn; Júnia Soares Hamdan
Journal: J Clin Microbiol Date: 2004-09 Impact factor: 5.948

3. Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic.

Authors: Jennifer R Pace; Albert M DeBerardinis; Vibhavari Sail; Silvia K Tacheva-Grigorova; Kelly A Chan; Raymond Tran; Daniel S Raccuia; Robert J Wechsler-Reya; M Kyle Hadden
Journal: J Med Chem Date: 2016-04-06 Impact factor: 7.446

Review 4. Overview of medically important antifungal azole derivatives.

Authors: R A Fromtling
Journal: Clin Microbiol Rev Date: 1988-04 Impact factor: 26.132

5. Oral and parenteral therapy with saperconazole (R 66905) of invasive aspergillosis in normal and immunocompromised animals.

Authors: J Van Cutsem; F Van Gerven; P A Janssen
Journal: Antimicrob Agents Chemother Date: 1989-12 Impact factor: 5.191

6. Effects of naftifine and terbinafine, two allylamine antifungal drugs, on selected functions of human polymorphonuclear leukocytes.

Authors: T Vago; G Baldi; D Colombo; M Barbareschi; G Norbiato; F Dallegri; M Bevilacqua
Journal: Antimicrob Agents Chemother Date: 1994-11 Impact factor: 5.191

Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones.

1. Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling.

2. In vitro susceptibilities of isolates of Sporothrix schenckii to itraconazole and terbinafine.

3. Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic.

Review 4. Overview of medically important antifungal azole derivatives.

5. Oral and parenteral therapy with saperconazole (R 66905) of invasive aspergillosis in normal and immunocompromised animals.

6. Effects of naftifine and terbinafine, two allylamine antifungal drugs, on selected functions of human polymorphonuclear leukocytes.

7. Molecular docking studies, biological evaluation and synthesis of novel 3-mercapto-1,2,4-triazole derivatives.

8. Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo.

9. Itraconazole, a new triazole that is orally active in aspergillosis.

Review 10. Mechanisms of triazole resistance in Aspergillus fumigatus.