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Literature DB >> 6097167

Itraconazole, a new triazole that is orally active in aspergillosis.

J Van Cutsem, F Van Gerven, M A Van de Ven, M Borgers, P A Janssen.

Abstract

Itraconazole is a new orally active triazole derivative with broad-spectrum antifungal activity. This drug is effective in experimental aspergillosis and possesses in vitro activity against various species and strains of Aspergillus. Morphological destruction of inoculated hyphae and complete inhibition of hyphal outgrowth in culture is obtained from 0.07 micrograms ml-1 (10(-7)M) onward. These properties make itraconazole a likely candidate for clinical evaluation in disseminated aspergillosis.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1984 PMID： 6097167 PMCID： PMC179958 DOI： 10.1128/AAC.26.4.527

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

9 in total

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24 in total

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Journal: Antimicrob Agents Chemother Date: 1993-12 Impact factor: 5.191

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