Literature DB >> 3355373

Studies on human immunodeficiency virus-induced cytopathic effects: use of human rhabdomyosarcoma (RD) cells.

A Srinivasan1, C S Goldsmith, D York, R Anand, P Luciw, G Schochetman, E Palmer, C Bohan.   

Abstract

A full-length molecular clone of human immunodeficiency virus (HIV) proviral DNA was transferred to human rhabdomyosarcoma (RD) cells by gene transfer method. RD cells released infectious virus within 12 hours after transfection and the viral particles present in the culture medium could be quantitated by monitoring reverse transcriptase activity. Chronic low level viral producer cell lines of RD were also established. Southern hybridization analysis revealed the presence of HIV sequences in transfected RD cells. Electron microscopic studies of the transfected cell revealed intracellular budding of HIV and also showed structural abnormalities such as giant cell phenotype and vacuolation. These features qualify RD cells as a useful system for studying the regulation and cytopathic effects of HIV.

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Year:  1988        PMID： 3355373     DOI： 10.1007/bf01311020

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  31 in total

1.  Transformation of mammalian cells with genes from procaryotes and eucaryotes.

Authors:  M Wigler; R Sweet; G K Sim; B Wold; A Pellicer; E Lacy; T Maniatis; S Silverstein; R Axel
Journal:  Cell       Date:  1979-04       Impact factor: 41.582

2.  Differential ability of human immunodeficiency virus isolates to productively infect human cells.

Authors:  L A Evans; T M McHugh; D P Stites; J A Levy
Journal:  J Immunol       Date:  1987-05-15       Impact factor: 5.422

3.  Pathologic features of AIDS encephalopathy in children: evidence for LAV/HTLV-III infection of brain.

Authors:  L R Sharer; L G Epstein; E S Cho; V V Joshi; M F Meyenhofer; L F Rankin; C K Petito
Journal:  Hum Pathol       Date:  1986-03       Impact factor: 3.466

4.  AIDS retrovirus (ARV-2) clone replicates in transfected human and animal fibroblasts.

Authors:  J A Levy; C Cheng-Mayer; D Dina; P A Luciw
Journal:  Science       Date:  1986-05-23       Impact factor: 47.728

5.  Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone.

Authors:  A Adachi; H E Gendelman; S Koenig; T Folks; R Willey; A Rabson; M A Martin
Journal:  J Virol       Date:  1986-08       Impact factor: 5.103

6.  The role of mononuclear phagocytes in HTLV-III/LAV infection.

Authors:  S Gartner; P Markovits; D M Markovitz; M H Kaplan; R C Gallo; M Popovic
Journal:  Science       Date:  1986-07-11       Impact factor: 47.728

7.  Retrovirus resembling HTLV in macrophages of patients with AIDS.

Authors:  F Gyorkey; J L Melnick; J G Sinkovics; P Gyorkey
Journal:  Lancet       Date:  1985-01-12       Impact factor: 79.321

8.  Molecular characterization of human immunodeficiency virus from Zaire: nucleotide sequence analysis identifies conserved and variable domains in the envelope gene.

Authors:  A Srinivasan; R Anand; D York; P Ranganathan; P Feorino; G Schochetman; J Curran; V S Kalyanaraman; P A Luciw; R Sanchez-Pescador
Journal:  Gene       Date:  1987       Impact factor: 3.688

9.  Susceptibility of human glial cells to infection with human immunodeficiency virus (HIV).

Authors:  S Dewhurst; J Bresser; M Stevenson; K Sakai; M J Evinger-Hodges; D J Volsky
Journal:  FEBS Lett       Date:  1987-03-09       Impact factor: 4.124

10.  Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS.

Authors:  J A Levy; A D Hoffman; S M Kramer; J A Landis; J M Shimabukuro; L S Oshiro
Journal:  Science       Date:  1984-08-24       Impact factor: 47.728
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  6 in total

1.  Human immunodeficiency virus (HIV) infection of cell cultures. An ultrastructural and immunocytochemical approach.

Authors:  G Cenacchi; M C Re; G Furlini; P Preda; G Pasquinelli; F Giangaspero; G N Martinelli
Journal:  Cytotechnology       Date:  1991-02       Impact factor: 2.058

2.  Generation of hybrid human immunodeficiency virus utilizing the cotransfection method and analysis of cellular tropism.

Authors:  A Velpandi; T Nagashunmugam; S Murthy; M Cartas; C Monken; A Srinivasan
Journal:  J Virol       Date:  1991-09       Impact factor: 5.103

3.  Generation of deletion mutants of simian immunodeficiency virus incapable of proviral integration.

Authors:  K Prakash; P N Ranganathan; R Mettus; P Reddy; A Srinivasan; S Plotkin
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

4.  vif-negative human immunodeficiency virus type 1 persistently replicates in primary macrophages, producing attenuated progeny virus.

Authors:  I H Chowdhury; W Chao; M J Potash; P Sova; H E Gendelman; D J Volsky
Journal:  J Virol       Date:  1996-08       Impact factor: 5.103

5.  Mutation in the primer binding site of the type 1 human immunodeficiency virus genome affects virus production and infectivity.

Authors:  T Nagashunmugam; A Velpandi; C S Goldsmith; S R Zaki; V S Kalyanaraman; A Srinivasan
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

6.  An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1.

Authors:  R Collman; J W Balliet; S A Gregory; H Friedman; D L Kolson; N Nathanson; A Srinivasan
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103
  6 in total

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