Literature DB >> 6328284

Cellular DNA region involved in induction of thymic lymphomas (Mlvi-2) maps to mouse chromosome 15.

P N Tsichlis, P G Strauss, C A Kozak.   

Abstract

Two cellular DNA regions representing common domains for proviral DNA integration ( Mlvi -1 and Mlvi -2) have been identified in Moloney murine leukemia virus-induced rat thymic lymphomas. Cellular sequences which were free of repeated DNA derived from a clone that defines the Mlvi -2 integration domain (lambda Cl228 ) were found to be highly conserved in a variety of vertebrate species that we examined, including mice, hamsters, cats, and humans. In this study, we identified the chromosomal map location of the Mlvi -2 homologous sequences in mice by using hamster-mouse somatic cell hybrids. The results show that Mlvi -2 is present on mouse chromosome 15 but is unrelated to the c-myc and c-sis proto-oncogenes, which map on the same chromosome. Since aberrations on chromosome 15 have been observed reproducibly in mouse thymomas, our data suggest that Mlvi -2 may define a novel sequence involved in the induction or progression of murine thymic lymphomas.

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Year:  1984        PMID： 6328284      PMCID： PMC368860          DOI： 10.1128/mcb.4.5.997-1000.1984

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  28 in total

1.  Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas.

Authors:  G S Payne; J M Bishop; H E Varmus
Journal:  Nature       Date:  1982-01-21       Impact factor: 49.962

2.  Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis.

Authors:  W S Hayward; B G Neel; S M Astrin
Journal:  Nature       Date:  1981-04-09       Impact factor: 49.962

Review 3.  Specific chromosomal translocations and the genesis of B-cell-derived tumors in mice and men.

Authors:  G Klein
Journal:  Cell       Date:  1983-02       Impact factor: 41.582

4.  Sequence comparison in the crossover region of an oncogenic avian retrovirus recombinant and its nononcogenic parent: genetic regions that control growth rate and oncogenic potential.

Authors:  P N Tsichlis; L Donehower; G Hager; N Zeller; R Malavarca; S Astrin; A M Skalka
Journal:  Mol Cell Biol       Date:  1982-11       Impact factor: 4.272

5.  Human oncogene locations and chromosome aberrations.

Authors:  J D Rowley
Journal:  Nature       Date:  1983-01-27       Impact factor: 49.962

6.  Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas.

Authors:  J M Adams; S Gerondakis; E Webb; L M Corcoran; S Cory
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

7.  Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.

Authors:  R Nusse; H E Varmus
Journal:  Cell       Date:  1982-11       Impact factor: 41.582

8.  Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertion.

Authors:  B G Neel; W S Hayward; H L Robinson; J Fang; S M Astrin
Journal:  Cell       Date:  1981-02       Impact factor: 41.582

9.  At least two regions of the viral genome determine the oncogenic potential of avian leukosis viruses.

Authors:  H L Robinson; B M Blais; P N Tsichlis; J M Coffin
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

10.  A common region for proviral DNA integration in MoMuLV-induced rat thymic lymphomas.

Authors:  P N Tsichlis; P G Strauss; L F Hu
Journal:  Nature       Date:  1983 Mar 31-Apr 6       Impact factor: 49.962
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  24 in total

Review 1.  Mouse chromosome 15.

Authors:  B A Mock; P E Neumann; J T Eppig; K E Huppi
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  Comparative molecular genetic analysis of lymphomas from six inbred mouse strains.

Authors:  M L Mucenski; H G Bedigian; M M Shull; N G Copeland; N A Jenkins
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

3.  Tumor progression in murine leukemia virus-induced T-cell lymphomas: monitoring clonal selections with viral and cellular probes.

Authors:  H T Cuypers; G C Selten; M Zijlstra; R E de Goede; C J Melief; A J Berns
Journal:  J Virol       Date:  1986-10       Impact factor: 5.103

Review 4.  Mouse chromosome 15.

Authors:  B Mock; P E Neumann; J T Eppig; K Huppi
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

5.  Roles of retrotransposons in benign and malignant hematologic disease.

Authors:  Anna M Schneider; Amy S Duffield; David E Symer; Kathleen H Burns
Journal:  Cellscience       Date:  2009-10-27

6.  Localization of a Moloney murine leukemia virus integration site gene, Mlvi2, on rat chromosome 2.

Authors:  T Kunieda; E Kobayashi; M Tachibana; H Ikadai
Journal:  Mamm Genome       Date:  1996-12       Impact factor: 2.957

Review 7.  Provirus tagging as an instrument to identify oncogenes and to establish synergism between oncogenes.

Authors:  A Berns
Journal:  Arch Virol       Date:  1988       Impact factor: 2.574

8.  Cellular DNA regions involved in the induction of rat thymic lymphomas (Mlvi-1, Mlvi-2, Mlvi-3, and c-myc) represent independent loci as determined by their chromosomal map location in the rat.

Authors:  P N Tsichlis; M A Lohse; C Szpirer; J Szpirer; G Levan
Journal:  J Virol       Date:  1985-12       Impact factor: 5.103

9.  Mouse chromosomal mapping of a murine leukemia virus integration region (Mis-1) first identified in rat thymic leukemia.

Authors:  P Jolicoeur; L Villeneuve; E Rassart; C Kozak
Journal:  J Virol       Date:  1985-12       Impact factor: 5.103

10.  Proviral integration site Mis-1 in rat thymomas corresponds to the pvt-1 translocation breakpoint in murine plasmacytomas.

Authors:  L Villeneuve; E Rassart; P Jolicoeur; M Graham; J M Adams
Journal:  Mol Cell Biol       Date:  1986-05       Impact factor: 4.272
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