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Literature DB >> 6324136

The nucleotide and deduced amino acid sequences of the encephalomyocarditis viral polyprotein coding region.

A C Palmenberg, E M Kirby, M R Janda, N L Drake, G M Duke, K F Potratz, M S Collett.

Abstract

The nucleotide sequence of 7200 bases of encephalomyocarditis (EMC) viral RNA, including the complete polyprotein-coding region, was determined. The polyprotein is encoded within a unique translational reading frame, 6870 bases in length. Protein synthesis begins with the sequence Met-Ala-Thr, and ends with the sequence Leu-Phe-Trp, 126 bases from the 3' end of the RNA. Viral capsid and noncapsid proteins were aligned with the deduced amino acid sequence of the polyprotein. The proteolytic processing map follows the standard 4-3-4 picornaviral pattern except for a short leader peptide (8 kd), which precedes the capsid proteins. Identification of the proteolytic cleavage sites showed that EMC viral protease, p22, has cleavage specificity for gln-gly or gln-ser sequences with adjacent proline residues. The cleavage specificity of the host-coded protease(s) includes both tyr-pro and gln-gly sequences.

Entities: Chemical Disease Gene

Mesh：

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Year: 1984 PMID： 6324136 PMCID： PMC318719 DOI： 10.1093/nar/12.6.2969

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

44 in total

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Journal: Virology Date: 1976-05 Impact factor: 3.616

3. Characterization of the large picornaviral polypeptides produced in the presence of zinc ion.

Authors: B E Butterworth; B D Korant
Journal: J Virol Date: 1974-08 Impact factor: 5.103

4. The initiation of protein synthesis directed by the RNA from encephalomyocarditis virus.

Authors: A E Smith
Journal: Eur J Biochem Date: 1973-03-01

5. Kinetics of synthesis and cleavage of encephalomyocarditis virus-specific proteins.

Authors: B E Butterworth; R R Rueckert
Journal: Virology Date: 1972-11 Impact factor: 3.616

6. Capsid polypeptides of mouse Elberfeld virus. I. Amino acid compositions and molar ratios in the virion.

Authors: C M Stoltzfus; R Rueckert
Journal: J Virol Date: 1972-09 Impact factor: 5.103

7. Virus-specific proteins synthesized in encephalomyocarditis virus-infected HeLa cells.

Authors: B E Butterworth; L Hall; C M Stoltzfus; R R Rueckert
Journal: Proc Natl Acad Sci U S A Date: 1971-12 Impact factor: 11.205

8. Gene order of encephalomyocarditis virus as determined by studies with pactamycin.

Authors: B E Butterworth; R R Rueckert
Journal: J Virol Date: 1972-05 Impact factor: 5.103

9. Polypeptide cleavages in the formation of poliovirus proteins.

Authors: M F Jacobson; D Baltimore
Journal: Proc Natl Acad Sci U S A Date: 1968-09 Impact factor: 11.205

10. Infection of mouse fibroblasts by cardioviruses: premature uncoating and its prevention by elevated pH and magnesium chloride.

Authors: L Hall; R R Rueckert
Journal: Virology Date: 1971-01 Impact factor: 3.616

90 in total

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2. Relationships among the positive strand and double-strand RNA viruses as viewed through their RNA-dependent RNA polymerases.

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3. Site-specific mutations at a picornavirus VP3/VP1 cleavage site disrupt in vitro processing and assembly of capsid precursors.

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4. Potential secondary and tertiary structure in the genomic RNA of foot and mouth disease virus.

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Journal: Nucleic Acids Res Date: 1987-09-11 Impact factor: 16.971

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Authors: J W Yoon; A K Wong; Y S Bae; H M Eun
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6. The late spliced 19S and 16S RNAs of simian virus 40 can be synthesized from a common pool of transcripts.

Authors: P J Good; R C Welch; W S Ryu; J E Mertz
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7. Small nuclear inclusion protein encoded by a plant potyvirus genome is a protease.

Authors: J C Carrington; W G Dougherty
Journal: J Virol Date: 1987-08 Impact factor: 5.103

8. Sequence determination of the capsid protein gene and flanking regions of tobacco etch virus: Evidence for synthesis and processing of a polyprotein in potyvirus genome expression.

Authors: R F Allison; J C Sorenson; M E Kelly; F B Armstrong; W G Dougherty
Journal: Proc Natl Acad Sci U S A Date: 1985-06 Impact factor: 11.205

9. Translation of poliovirus RNA: role of an essential cis-acting oligopyrimidine element within the 5' nontranslated region and involvement of a cellular 57-kilodalton protein.

Authors: T V Pestova; C U Hellen; E Wimmer
Journal: J Virol Date: 1991-11 Impact factor: 5.103

10. Similarity in gene organization and homology between proteins of animal picornaviruses and a plant comovirus suggest common ancestry of these virus families.

Authors: P Argos; G Kamer; M J Nicklin; E Wimmer
Journal: Nucleic Acids Res Date: 1984-09-25 Impact factor: 16.971