Literature DB >> 6323996

Non-function of a Moloney murine leukaemia virus regulatory sequence in F9 embryonal carcinoma cells.

E Linney, B Davis, J Overhauser, E Chao, H Fan.   

Abstract

Moloney murine leukaemia virus (M-MuLV) infection of embryonal carcinoma (EC) cells results in the integration of proviral DNA into the host cell genome, but not in virus production. One suggested explanation for the lack of viral gene expression in EC cells has been methylation of the integrated viral DNA. However, subsequent reports indicated that integration of the M-MuLV DNA occurs soon after infection, but that viral DNA methylation occurs considerably later. Nevertheless, viral gene expression is not observed even at early times. One possible explanation is that certain M-MuLV regulatory sequences do not function in EC cells. We now present evidence which supports this hypothesis.

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Year:  1984        PMID： 6323996     DOI： 10.1038/308470a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  118 in total

1.  Appearance of mink cell focus-inducing recombinants during in vivo infection by moloney murine leukemia virus (M-MuLV) or the Mo+PyF101 M-MuLV enhancer variant: implications for sites of generation and roles in leukemogenesis.

Authors:  J K Lander; B Chesebro; H Fan
Journal:  J Virol       Date:  1999-07       Impact factor: 5.103

2.  Lack of shielding of primer binding site silencer-mediated repression of an internal promoter in a retrovirus vector by the putative insulators scs, BEAD-1, and HS4.

Authors:  C Modin; F S Pedersen; M Duch
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

3.  Evaluation of residual promoter activity in γ-retroviral self-inactivating (SIN) vectors.

Authors:  Wenqin Xu; Jill L Russ; Maribeth V Eiden
Journal:  Mol Ther       Date:  2011-10-18       Impact factor: 11.454

4.  Negative regulation of the major histocompatibility complex class I promoter in embryonal carcinoma cells.

Authors:  J R Flanagan; M Murata; P A Burke; Y Shirayoshi; E Appella; P A Sharp; K Ozato
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

5.  Promoter interactions in retrovirus vectors introduced into fibroblasts and embryonic stem cells.

Authors:  P Soriano; G Friedrich; P Lawinger
Journal:  J Virol       Date:  1991-05       Impact factor: 5.103

6.  Biological activities of oligonucleotides spanning the F9 point mutation within the enhancer region of polyomavirus DNA.

Authors:  M Satake; K Furukawa; Y Ito
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

7.  Enhancer sequences of a retroviral vector determine expression of a gene in multipotent hematopoietic progenitors and committed erythroid cells.

Authors:  C A Holland; P Anklesaria; M A Sakakeeny; J S Greenberger
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

8.  Analysis of the binding proteins and activity of the long terminal repeat of Moloney murine leukemia virus during differentiation of mouse embryonal carcinoma cells.

Authors:  T Tsukiyama; O Niwa; K Yokoro
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

9.  Development of a retroviral vector for inducible expression of transforming growth factor beta 1.

Authors:  M L McGeady; P M Arthur; M Seidman
Journal:  J Virol       Date:  1990-07       Impact factor: 5.103

10.  Derivatives of Moloney murine sarcoma virus capable of being transcribed in embryonal carcinoma stem cells have gained a functional Sp1 binding site.

Authors:  V E Prince; P W Rigby
Journal:  J Virol       Date:  1991-04       Impact factor: 5.103
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