Literature DB >> 6323614

Rat lymphoid cell lines with human T cell leukemia virus production. I. Biological and serological characterization.

M Tateno, N Kondo, T Itoh, T Chubachi, T Togashi, T Yoshiki.   

Abstract

Cocultivation of spleen cells, lymph node cells, and thymocytes of female Wistar-King-Aptekman rats with short-term cultured male adult T cell leukemia (ATL) cells in the presence of 5-bromo-2'-deoxyuridine (BrdUrd) resulted in the establishment of rat lymphoid cell lines, TARS-1, TARL-2, and TART-1. Cytogenetic analysis of the three cell lines showed a female rat karyotype with 42 chromosomes. The surface phenotypes of TARS-1 and TART-1 were those of rat T cells. TARL-2 was only positive for rat Ia and leukocyte common antigens. The cell lines continuously produced a type C retrovirus, human T cell leukemia virus (HTLV) and expressed ATL-associated antigens. TARS-1 and TART-1, but not TARL-2 were transplantable into newborn syngeneic rats and nude mice. These results strongly indicate that HTLV not only immortalizes, but also transforms rat T cells in vitro. Adult rats immunized with either TARS-1 or TARL-2 produced antibodies specific for HTLV. The biochemical analysis of the antigens that reacted with rat sera revealed that they are the two HTLV-specific polypeptides, p24 and p28.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6323614      PMCID： PMC2187267          DOI： 10.1084/jem.159.4.1105

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  27 in total

1.  Adult T-cell leukemia: clinical and hematologic features of 16 cases.

Authors:  T Uchiyama; J Yodoi; K Sagawa; K Takatsuki; H Uchino
Journal:  Blood       Date:  1977-09       Impact factor: 22.113

2.  Biological expression of antigenic determinants of murine leukemia virus proteins gp69-71 and p30.

Authors:  H Ikeda; T Pincus; T Yoshiki; M Strand; J T August; E A Boyse; R C Mellors
Journal:  J Virol       Date:  1974-11       Impact factor: 5.103

3.  Thymus dependence of cells in peripheral lymphoid tissues and in the circulation sensitive to natural thymocytotoxic autoantibody in NZB mice.

Authors:  T Shirai; T Yoshiki; R C Mellors
Journal:  J Immunol       Date:  1972-07       Impact factor: 5.422

4.  Isolation of a new type C retrovirus (HTLV) in primary uncultured cells of a patient with Sézary T-cell leukaemia.

Authors:  B J Poiesz; F W Ruscetti; M S Reitz; V S Kalyanaraman; R C Gallo
Journal:  Nature       Date:  1981-11-19       Impact factor: 49.962

5.  A novel T-cell line derived from adult T-cell leukemia.

Authors:  I Miyoshi; I Kubonishi; M Sumida; S Hiraki; T Tsubota; I Kimura; K Miyamoto; J Sato
Journal:  Gan       Date:  1980-02

6.  Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

Authors:  Y Hinuma; K Nagata; M Hanaoka; M Nakai; T Matsumoto; K I Kinoshita; S Shirakawa; I Miyoshi
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

7.  Characterization and distribution of nucleic acid sequences of a novel type C retrovirus isolated from neoplastic human T lymphocytes.

Authors:  M S Reitz; B J Poiesz; F W Ruscetti; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

8.  Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.

Authors:  B J Poiesz; F W Ruscetti; A F Gazdar; P A Bunn; J D Minna; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

9.  Common cell surface antigen associated with mammalian C-type RNA viruses. Cell membrane-bound gs antigen.

Authors:  T Yoshiki; R C Mellors; W D Hardy; E Fleissner
Journal:  J Exp Med       Date:  1974-04-01       Impact factor: 14.307

10.  The viral envelope glycoprotein of murine leukemia virus and the pathogenesis of immune complex glomerulonephritis of New Zealand mice.

Authors:  T Yoshiki; R C Mellors; M Strand; J T August
Journal:  J Exp Med       Date:  1974-10-01       Impact factor: 14.307
View more
  31 in total

1.  Development of human T-cell leukemia virus type 1-transformed tumors in rats following suppression of T-cell immunity by CD80 and CD86 blockade.

Authors:  S Hanabuchi; T Ohashi; Y Koya; H Kato; F Takemura; K Hirokawa; T Yoshiki; H Yagita; K Okumura; M Kannagi
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

2.  De novo human T-cell leukemia virus type 1 infection of human lymphocytes in NOD-SCID, common gamma-chain knockout mice.

Authors:  Paola Miyazato; Jun-ichirou Yasunaga; Yuko Taniguchi; Yoshio Koyanagi; Hiroaki Mitsuya; Masao Matsuoka
Journal:  J Virol       Date:  2006-08-30       Impact factor: 5.103

3.  p27x-III and p21x-III, proteins encoded by the pX sequence of human T-cell leukemia virus type I.

Authors:  T Kiyokawa; M Seiki; S Iwashita; K Imagawa; F Shimizu; M Yoshida
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

4.  Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction.

Authors:  T Kinoshita; M Shimoyama; K Tobinai; M Ito; S Ito; S Ikeda; K Tajima; K Shimotohno; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

5.  Immunocytochemical and ultrastructural characterization of human T-lymphotropic virus type I (HTLV-I)-producing rabbit lymphoid cell lines.

Authors:  Y Ohtsuki; I Miyoshi; T Oka; K Hayashi; K Takahashi; M Furihata; J Iwata; T Takeuchi; H Sonobe
Journal:  Arch Virol       Date:  1988       Impact factor: 2.574

6.  Induction of adult T-cell leukemia-like lymphoproliferative disease and its inhibition by adoptive immunotherapy in T-cell-deficient nude rats inoculated with syngeneic human T-cell leukemia virus type 1-immortalized cells.

Authors:  T Ohashi; S Hanabuchi; H Kato; Y Koya; F Takemura; K Hirokawa; T Yoshiki; Y Tanaka; M Fujii; M Kannagi
Journal:  J Virol       Date:  1999-07       Impact factor: 5.103

7.  Subacute progression of human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis.

Authors:  Marco A Lima; Ramza C Harab; Doris Schor; Maria J Andrada-Serpa; Abelardo Q C Araújo
Journal:  J Neurovirol       Date:  2007-10       Impact factor: 2.643

8.  Phenotypic progression of a rat lymphoid cell line immortalized by human T-lymphotropic virus type I to induce lymphoma/leukemia-like disease in rats.

Authors:  T Oka; H Sonobe; J Iwata; I Kubonishi; H Satoh; M Takata; Y Tanaka; M Tateno; H Tozawa; S Mori
Journal:  J Virol       Date:  1992-11       Impact factor: 5.103

9.  Correlation of major histocompatibility complex class I downregulation with resistance of human T-cell leukemia virus type 1-infected T cells to cytotoxic T-lymphocyte killing in a rat model.

Authors:  Takashi Ohashi; Shino Hanabuchi; Reiko Suzuki; Hirotomo Kato; Takao Masuda; Mari Kannagi
Journal:  J Virol       Date:  2002-07       Impact factor: 5.103

10.  Envelope proteins of human T-cell leukemia virus: expression in Escherichia coli and its application to studies of env gene functions.

Authors:  T Kiyokawa; H Yoshikura; S Hattori; M Seiki; M Yoshida
Journal:  Proc Natl Acad Sci U S A       Date:  1984-10       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.