Literature DB >> 4139291

Biological expression of antigenic determinants of murine leukemia virus proteins gp69-71 and p30.

H Ikeda, T Pincus, T Yoshiki, M Strand, J T August, E A Boyse, R C Mellors.   

Abstract

Antisera to purified structural proteins of Rauscher murine leukemia virus, the major envelope glycoprotein, gp69/71, and the major internal protein, p30, were studied by immunofluorescence of viable and fixed virus-infected cells and by virus neutralization. Group-specific and type-specific determinants of gp69/71 were demonstrated by immunofluorescence and virus neutralization tests, indicating that these determinants are located in the cytoplasm and probably on the cell surface as well as on virus envelope. Antisera against p30 showed anti-group and anti-interspecies activities by immunofluorescence with no virus-neutralizing activity. Both antigenic determinants of gp69/71 were sensitive to guanidine-hydrochloride and to a lesser degree to ether treatment, whereas the group-specific determinants of p30 were relatively stable to these treatments.

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Year:  1974        PMID： 4139291      PMCID： PMC355645     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

1.  Glycoprotein components of avian and murine RNA tumor viruses.

Authors:  P H Duesberg; G S Martin; P K Vogt
Journal:  Virology       Date:  1970-08       Impact factor: 3.616

2.  Coexistence of intraspecies and interspecies specific antigenic determinants on the major structural polypeptide of mammalian C-type viruses.

Authors:  R V Gilden; S Oroszlan; R J Huebner
Journal:  Nat New Biol       Date:  1971-05-26

3.  Complement fixation and tissue culture assays for mouse leukemia viruses.

Authors:  J W Hartley; W P Rowe; W I Capps; R J Huebner
Journal:  Proc Natl Acad Sci U S A       Date:  1965-05       Impact factor: 11.205

4.  The G (Gross) leukemia antigen.

Authors:  L J Old; E A Boyse; E Stockert
Journal:  Cancer Res       Date:  1965-07       Impact factor: 12.701

5.  Mixed culture cytopathogenicity: a new test for growth of murine leukemia viruses in tissue culture.

Authors:  V Klement; W P Rowe; J W Hartley; W E Pugh
Journal:  Proc Natl Acad Sci U S A       Date:  1969-07       Impact factor: 11.205

6.  Isolation and some characteristics of a group-specific antigen of the murine leukemia viruses.

Authors:  A Gregoriades; L J Old
Journal:  Virology       Date:  1969-02       Impact factor: 3.616

Review 7.  Antigens of tumors and leukemias induced by viruses.

Authors:  L J Old; E A Boyse
Journal:  Fed Proc       Date:  1965 Sep-Oct

8.  Plaque assay techniques for murine leukemia viruses.

Authors:  W P Rowe; W E Pugh; J W Hartley
Journal:  Virology       Date:  1970-12       Impact factor: 3.616

9.  Proteins of the murine C-type RNA tumour viruses: isolation of a group-specific antigen by isoelectric focusing.

Authors:  S Oroszlan; C L Fisher; T B Stanley; R V Gilden
Journal:  J Gen Virol       Date:  1970-07       Impact factor: 3.891

10.  Host-range restrictions of murine leukemia viruses in mouse embryo cell cultures.

Authors:  J W Hartley; W P Rowe; R J Huebner
Journal:  J Virol       Date:  1970-02       Impact factor: 5.103
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  26 in total

1.  Chromatographic Separation and Antigenic Analysis of Proteins of the Oncornaviruses IV. Biochemical Typing of Murine Viral Proteins.

Authors:  D L Buchhagen; O Stutman; E Fleissner
Journal:  J Virol       Date:  1975-05       Impact factor: 5.103

2.  Chromatographic separation and antigenic analysis of proteins of the oncornaviruses. V. Identification of a new murine viral protein, p15(E).

Authors:  H Ikeda; W Hardy; E Tress; E Fleissner
Journal:  J Virol       Date:  1975-07       Impact factor: 5.103

3.  Location of antigens associated with bovine leukemia virus.

Authors:  M Onuma; D M Driscoli; C Olson
Journal:  Arch Virol       Date:  1977       Impact factor: 2.574

4.  Genomic diversity of the acquired immunodeficiency syndrome retroviruses is reflected in alteration of its translational products.

Authors:  S G Devare; A Srinivasan; C A Bohan; T J Spira; J W Curran; V S Kalyanaraman
Journal:  Proc Natl Acad Sci U S A       Date:  1986-08       Impact factor: 11.205

5.  Molecular cloning and primary nucleotide sequence analysis of a distinct human immunodeficiency virus isolate reveal significant divergence in its genomic sequences.

Authors:  S M Desai; V S Kalyanaraman; J M Casey; A Srinivasan; P R Andersen; S G Devare
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

6.  Biochemical and immunological characterization of the major envelope glycoprotein of bovine leukemia virus.

Authors:  S G Devare; J R Stephenson
Journal:  J Virol       Date:  1977-08       Impact factor: 5.103

7.  Biochemical and immunological characterization of the major envelope glycoprotein gp69/71 and degradation fragments from Rauscher leukemia virus.

Authors:  M J Krantz; M Strand; J T August
Journal:  J Virol       Date:  1977-06       Impact factor: 5.103

8.  Expression of antigenic crossreactivity to RD114 p 30 protein in a human fibrosarcoma cell line.

Authors:  H S Smith; J L Riggs; E L Springer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

9.  Radiommunoassays for the 70,000-molecular-weight glycoproteins of endogenous mouse type C viruses: viral antigen expression in normal mouse tissues and sera.

Authors:  S Hino; J R Stephenson; S A Aaronson
Journal:  J Virol       Date:  1976-06       Impact factor: 5.103

10.  Relation between common antigen and membrane antigens associated with Marek's disease herpesvirus and turkey herpesvirus infections.

Authors:  M Onuma; T Mikami; T T Hayashi
Journal:  Arch Virol       Date:  1976       Impact factor: 2.574
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