Literature DB >> 6320855

The use of recombinant DNA plasmids for the determination of DNA-repair and recombination in cultured mammalian cells.

R Cox, W K Masson, P G Debenham, M B Webb.   

Abstract

Using the recombinant plasmid pSV2gpt and DNA transfer techniques, cell mediated DNA ligation and recombination of plasmid DNA have been demonstrated in four human cell lines. Data suggesting the involvement of a possible defect in the cellular equilibrium between ligation and exonuclease digestion of double strand DNA scissions in an ataxia-telangiectasia (A-T) cell line is discussed. The same A-T line was grossly proficient in DNA recombination but it will be necessary to distinguish between recombination in coding and non-coding plasmid sequences.

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Year:  1984        PMID： 6320855      PMCID： PMC2149177     

Source DB:  PubMed          Journal:  Br J Cancer Suppl        ISSN： 0306-9443


  4 in total

1.  Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity.

Authors:  A M Taylor; D G Harnden; C F Arlett; S A Harcourt; A R Lehmann; S Stevens; B A Bridges
Journal:  Nature       Date:  1975-12-04       Impact factor: 49.962

2.  Properties of a supercoiled deoxyribonucleic acid-protein relaxation complex and strand specificity of the relaxation event.

Authors:  D B Clewell; D R Helinski
Journal:  Biochemistry       Date:  1970-10-27       Impact factor: 3.162

3.  Mapping temperature-sensitive and host-range mutations of adenovirus type 5 by marker rescue.

Authors:  E Frost; J Williams
Journal:  Virology       Date:  1978-11       Impact factor: 3.616

4.  Factors governing the expression of a bacterial gene in mammalian cells.

Authors:  R C Mulligan; P Berg
Journal:  Mol Cell Biol       Date:  1981-05       Impact factor: 4.272
  4 in total
  8 in total

1.  The RAD5 gene product is involved in the avoidance of non-homologous end-joining of DNA double strand breaks in the yeast Saccharomyces cerevisiae.

Authors:  F Ahne; B Jha; F Eckardt-Schupp
Journal:  Nucleic Acids Res       Date:  1997-02-15       Impact factor: 16.971

2.  Recombination and ligation of transfected DNA in CHO mutant EM9, which has high levels of sister chromatid exchange.

Authors:  C A Hoy; J C Fuscoe; L H Thompson
Journal:  Mol Cell Biol       Date:  1987-05       Impact factor: 4.272

3.  Carcinogens can induce homologous recombination between duplicated chromosomal sequences in mouse L cells.

Authors:  Y Y Wang; V M Maher; R M Liskay; J J McCormick
Journal:  Mol Cell Biol       Date:  1988-01       Impact factor: 4.272

Review 4.  Drug resistance and DNA repair.

Authors:  M Fox; J J Roberts
Journal:  Cancer Metastasis Rev       Date:  1987       Impact factor: 9.264

5.  Differential level of DSB repair fidelity effected by nuclear protein extracts derived from radiosensitive and radioresistant human tumour cells.

Authors:  R A Britten; D Liu; S Kuny; M J Allalunis-Turner
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

Review 6.  Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man. Progress in the elucidation of the underlying biochemical defect.

Authors:  P J McKinnon
Journal:  Hum Genet       Date:  1987-03       Impact factor: 4.132

7.  Reduced DNA topoisomerase II activity in ataxia-telangiectasia cells.

Authors:  S P Singh; R Mohamed; C Salmond; M F Lavin
Journal:  Nucleic Acids Res       Date:  1988-05-11       Impact factor: 16.971

8.  Modification of non-conservative double-strand break (DSB) rejoining activity after the induction of cisplatin resistance in human tumour cells.

Authors:  R A Britten; S Kuny; S Perdue
Journal:  Br J Cancer       Date:  1999-02       Impact factor: 7.640
  8 in total

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