Literature DB >> 6320812

Spin label studies on synaptosomal membranes of rat brain cortex during aging.

K Nagy, P Simon, I Zs-Nagy.   

Abstract

Membrane lipids of brain synaptosomes of 2, 12 and 24 months old rats were labeled by stearic acid spin probes with a doxyl group in the C-5 and C-16 position, respectively. We demonstrated that the hydrophobic region of synaptosomal membranes became more rigid during the life span studied, and the region located nearer the surface of membranes displays a significantly decreased fluidity only in the oldest group. Membrane proteins labeled with a nitroxide derivative of maleimide suggest that conformational changes take place during aging.

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Year:  1983        PMID： 6320812     DOI： 10.1016/0006-291x(83)91652-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

1.  The effects of phosphatidylserine on the decreased cardiovascular response to clonidine microinfused into the nucleus tractus solitarii of old rats.

Authors:  V Mollace; Y Masuda; T Pelaggi; G Nisticò
Journal:  Br J Pharmacol       Date:  1990-07       Impact factor: 8.739

2.  Iron-induced lipid peroxidation and inhibition of dopamine synthesis in striatum synaptosomes.

Authors:  M M Zaleska; K Nagy; R A Floyd
Journal:  Neurochem Res       Date:  1989-07       Impact factor: 3.996

3.  Effect of hyperbaric oxygenation on the Na+, K(+)-ATPase and membrane fluidity of cerebrocortical membranes after experimental subarachnoid hemorrhage.

Authors:  K Yufu; T Itoh; R Edamatsu; A Mori; M Hirakawa
Journal:  Neurochem Res       Date:  1993-09       Impact factor: 3.996

4.  Effects of aging on the composition and metabolism of docosahexaenoate-containing lipids of retina.

Authors:  N P Rotstein; M G Ilincheta de Boschero; N M Giusto; M I Aveldaño
Journal:  Lipids       Date:  1987-04       Impact factor: 1.880

5.  Microinfusion of clonidine and yohimbine into locus coeruleus alters EEG power spectrum: effects of aging and reversal by phosphatidylserine.

Authors:  G B de Sarro; G Bagetta; C Ascioti; V Libri; G Nisticò
Journal:  Br J Pharmacol       Date:  1988-12       Impact factor: 8.739
  5 in total

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