Literature DB >> 6320016

Expression of functional acetylcholine receptor from cloned cDNAs.

M Mishina, T Kurosaki, T Tobimatsu, Y Morimoto, M Noda, T Yamamoto, M Terao, J Lindstrom, T Takahashi, M Kuno.   

Abstract

The cloned cDNAs encoding the four subunits of the Torpedo californica acetylcholine receptor, each carried by a simian virus 40 vector, direct the synthesis of the functional receptor in a combined expression system consisting of COS monkey cells and Xenopus oocytes. Our results suggest that all four subunits are required to elicit a normal nicotinic response to acetylcholine, whereas only the alpha-subunit is indispensable for alpha-bungarotoxin binding activity.

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Year:  1984        PMID： 6320016     DOI： 10.1038/307604a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  81 in total

1.  Biphasic, opposing modulation of cloned neuronal alpha1E Ca channels by distinct signaling pathways coupled to M2 muscarinic acetylcholine receptors.

Authors:  U Meza; R Bannister; K Melliti; B Adams
Journal:  J Neurosci       Date:  1999-08-15       Impact factor: 6.167

Review 2.  Nicotinic receptor-associated 43K protein and progressive stabilization of the postsynaptic membrane.

Authors:  J A Hill
Journal:  Mol Neurobiol       Date:  1992       Impact factor: 5.590

3.  Inhibition of human immunodeficiency virus type 1 Rev function by a Rev mutant which interferes with nuclear/nucleolar localization of Rev.

Authors:  S Kubota; R Furuta; M Maki; M Hatanaka
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103

Review 4.  Use of Xenopus oocytes for the functional expression of plasma membrane proteins.

Authors:  E Sigel
Journal:  J Membr Biol       Date:  1990-09       Impact factor: 1.843

Review 5.  Desensitization of the nicotinic acetylcholine receptor: molecular mechanisms and effect of modulators.

Authors:  E L Ochoa; A Chattopadhyay; M G McNamee
Journal:  Cell Mol Neurobiol       Date:  1989-06       Impact factor: 5.046

6.  Expression of avian Ca2+-ATPase in cultured mouse myogenic cells.

Authors:  N J Karin; Z Kaprielian; D M Fambrough
Journal:  Mol Cell Biol       Date:  1989-05       Impact factor: 4.272

7.  Coupling of inositol phospholipid hydrolysis to peptide hormone receptors expressed from adrenal and pituitary mRNA in Xenopus laevis oocytes.

Authors:  R P McIntosh; K J Catt
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

8.  Spontaneous and agonist-induced openings of an acetylcholine receptor channel composed of bovine muscle alpha-, beta- and delta-subunits.

Authors:  M B Jackson; K Imoto; M Mishina; T Konno; S Numa; B Sakmann
Journal:  Pflugers Arch       Date:  1990-10       Impact factor: 3.657

9.  A region of basic amino-acid cluster in HIV-1 Tat protein is essential for trans-acting activity and nucleolar localization.

Authors:  S Endo; S Kubota; H Siomi; A Adachi; S Oroszlan; M Maki; M Hatanaka
Journal:  Virus Genes       Date:  1989-11       Impact factor: 2.332

10.  Genetic alteration of catecholamine specificity in transgenic mice.

Authors:  K Kobayashi; T Sasaoka; S Morita; I Nagatsu; A Iguchi; Y Kurosawa; K Fujita; T Nomura; M Kimura; M Katsuki
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-01       Impact factor: 11.205
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