Literature DB >> 6319760

Immunological characterization of herpes simplex virus type 1 and 2 polypeptide(s) involved in viral ribonucleotide reductase activity.

S Bacchetti, M J Evelegh, B Muirhead, C S Sartori, D Huszar.   

Abstract

Mammalian cells infected with herpes simplex virus (HSV) express a novel ribonucleotide reductase which is biochemically and immunologically distinct from the uninfected-cell enzyme. Using polyvalent rabbit antiserum raised against partially purified HSV type 2 reductase as well as monoclonal antibodies to HSV type 1 and HSV type 2 early antigens, we have been able to show that in both serotypes reductase activity is associated with phosphoproteins of molecular weights 144,000 and 38,000 encoded between map units 0.566 and 0.602 in the viral genomes. The major antigenic species (144,000) have been tentatively identified as HSV type 1 ICP6 and HSV type 2 ICP10.

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Year:  1984        PMID： 6319760      PMCID： PMC255503     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  17 in total

1.  Polypeptide synthesized in herpes simplex virus type 2-infected HEp-2 cells.

Authors:  K L Powell; R J Courtney
Journal:  Virology       Date:  1975-07       Impact factor: 3.616

Review 2.  Reduction of ribonucleotides.

Authors:  L Thelander; P Reichard
Journal:  Annu Rev Biochem       Date:  1979       Impact factor: 23.643

3.  Antigenic differences between isolates of herpesvirus type 2.

Authors:  P Seth; W E Rawls; R Duff; F Rapp; E Adam; J L Melnick
Journal:  Intervirology       Date:  1974       Impact factor: 1.763

4.  Partial purification and characterization of the ribonucleotide reductase induced by herpes simplex virus infection of mammalian cells.

Authors:  D Huszar; S Bacchetti
Journal:  J Virol       Date:  1981-02       Impact factor: 5.103

5.  Detailed characterization of an apparently unspliced beta herpes simplex virus type 1 gene mapping in the interior of another.

Authors:  K G Draper; R J Frink; E K Wagner
Journal:  J Virol       Date:  1982-09       Impact factor: 5.103

6.  Ribonucleotide reductase induced by herpes simplex virus has a virus-specified constituent.

Authors:  B M Dutia
Journal:  J Gen Virol       Date:  1983-03       Impact factor: 3.891

7.  Organization of the herpes simplex virus type 1 transcription unit encoding two early proteins with molecular weights of 140000 and 40000.

Authors:  J McLauchlan; J B Clements
Journal:  J Gen Virol       Date:  1983-05       Impact factor: 3.891

8.  Ribonucleotide reductase from herpes simplex virus (types 1 and 2) infected and uninfected KB cells: properties of the partially purified enzymes.

Authors:  M Ponce de Leon; R J Eisenberg; G H Cohen
Journal:  J Gen Virol       Date:  1977-07       Impact factor: 3.891

9.  Multienzyme complex for metabolic channeling in mammalian DNA replication.

Authors:  G Prem veer Reddy; A B Pardee
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

10.  Herpes simplex virus-induced ribonucleotide reductase: development of antibodies specific for the enzyme.

Authors:  D Huszar; S Beharry; S Bacchetti
Journal:  J Gen Virol       Date:  1983-06       Impact factor: 3.891
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  20 in total

1.  Herpes simplex virus specifies two subunits of ribonucleotide reductase encoded by 3'-coterminal transcripts.

Authors:  M A Swain; D A Galloway
Journal:  J Virol       Date:  1986-03       Impact factor: 5.103

2.  Neutralization of herpes simplex virus ribonucleotide reductase activity by an oligopeptide-induced antiserum directed against subunit H2.

Authors:  E A Cohen; P Gaudreau; P Brazeau; Y Langelier
Journal:  J Virol       Date:  1986-12       Impact factor: 5.103

3.  Identification of immediate-early-type cis-response elements in the promoter for the ribonucleotide reductase large subunit from herpes simplex virus type 2.

Authors:  J P Wymer; T D Chung; Y N Chang; G S Hayward; L Aurelian
Journal:  J Virol       Date:  1989-06       Impact factor: 5.103

4.  Protein kinase activity associated with the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10).

Authors:  T D Chung; J P Wymer; C C Smith; M Kulka; L Aurelian
Journal:  J Virol       Date:  1989-08       Impact factor: 5.103

5.  Herpes simplex virus type 1-induced ribonucleotide reductase activity is dispensable for virus growth and DNA synthesis: isolation and characterization of an ICP6 lacZ insertion mutant.

Authors:  D J Goldstein; S K Weller
Journal:  J Virol       Date:  1988-01       Impact factor: 5.103

6.  Cells that constitutively express the herpes simplex virus immediate-early protein ICP4 allow efficient activation of viral delayed-early genes in trans.

Authors:  R H Persson; S Bacchetti; J R Smiley
Journal:  J Virol       Date:  1985-05       Impact factor: 5.103

7.  The small subunit of ribonucleotide reductase is encoded by one of the most abundant translationally regulated maternal RNAs in clam and sea urchin eggs.

Authors:  N M Standart; S J Bray; E L George; T Hunt; J V Ruderman
Journal:  J Cell Biol       Date:  1985-06       Impact factor: 10.539

8.  Multistep transformation by defined fragments of herpes simplex virus type 2 DNA: oncogenic region and its gene product.

Authors:  Y Hayashi; T Iwasaka; C C Smith; L Aurelian; G K Lewis; P O Ts'o
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

9.  Identification and separation of the two subunits of the herpes simplex virus ribonucleotide reductase.

Authors:  S Bacchetti; M J Evelegh; B Muirhead
Journal:  J Virol       Date:  1986-03       Impact factor: 5.103

10.  Evaluation of a peptidomimetic ribonucleotide reductase inhibitor with a murine model of herpes simplex virus type 1 ocular disease.

Authors:  C R Brandt; B Spencer; P Imesch; M Garneau; R Déziel
Journal:  Antimicrob Agents Chemother       Date:  1996-05       Impact factor: 5.191
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