Literature DB >> 3005618

Identification and separation of the two subunits of the herpes simplex virus ribonucleotide reductase.

S Bacchetti, M J Evelegh, B Muirhead.   

Abstract

The herpes simplex virus ribonucleotide reductase is associated with two viral proteins which are both immunoprecipitated by monoclonal antibodies specific for the enzyme. We separated the two proteins and showed that individual antibodies react solely with one or the other. In addition, antibodies to either protein can neutralize enzymatic activity. Our data demonstrate that the proteins are associated in a complex and constitute the subunits of the enzyme.

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Substances：

Year:  1986        PMID： 3005618      PMCID： PMC252856     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  16 in total

1.  Reconstitution of the ribonucleotide reductase enzyme from Ehrlich tumor cells.

Authors:  J G Cory; A E Fleischer; J B Munro
Journal:  J Biol Chem       Date:  1978-05-10       Impact factor: 5.157

2.  Partial purification and characterization of the ribonucleotide reductase induced by herpes simplex virus infection of mammalian cells.

Authors:  D Huszar; S Bacchetti
Journal:  J Virol       Date:  1981-02       Impact factor: 5.103

3.  Is ribonucleotide reductase the transforming function of herpes simplex virus 2?

Authors:  D Huszar; S Bacchetti
Journal:  Nature       Date:  1983-03-03       Impact factor: 49.962

4.  Ribonucleotide reductase induced by herpes simplex virus has a virus-specified constituent.

Authors:  B M Dutia
Journal:  J Gen Virol       Date:  1983-03       Impact factor: 3.891

5.  Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

Authors:  P J Southern; P Berg
Journal:  J Mol Appl Genet       Date:  1982

Review 6.  Regulation of ribonucleotide reductase.

Authors:  A Holmgren
Journal:  Curr Top Cell Regul       Date:  1981

7.  Ribonucleotide reductase from calf thymus. Separation of the enzyme into two nonidentical subunits, proteins M1 and M2.

Authors:  L Thelander; S Eriksson; M Akerman
Journal:  J Biol Chem       Date:  1980-08-10       Impact factor: 5.157

8.  The ribonucleotide reductase induced by herpes simplex virus type 1 involves minimally a complex of two polypeptides (136K and 38K).

Authors:  M C Frame; H S Marsden; B M Dutia
Journal:  J Gen Virol       Date:  1985-07       Impact factor: 3.891

9.  Herpes simplex virus-induced ribonucleotide reductase: development of antibodies specific for the enzyme.

Authors:  D Huszar; S Beharry; S Bacchetti
Journal:  J Gen Virol       Date:  1983-06       Impact factor: 3.891

10.  Monoclonal antibodies to herpes simplex viruses: use in antigenic typing and rapid diagnosis.

Authors:  L C Goldstein; L Corey; J K McDougall; E Tolentino; R C Nowinski
Journal:  J Infect Dis       Date:  1983-05       Impact factor: 5.226
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  17 in total

Review 1.  HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part I. HSV-1 structure, replication and pathogenesis.

Authors:  A Jacobs; X O Breakefield; C Fraefel
Journal:  Neoplasia       Date:  1999-11       Impact factor: 5.715

2.  Neutralization of herpes simplex virus ribonucleotide reductase activity by an oligopeptide-induced antiserum directed against subunit H2.

Authors:  E A Cohen; P Gaudreau; P Brazeau; Y Langelier
Journal:  J Virol       Date:  1986-12       Impact factor: 5.103

3.  High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: mutant viruses altered in its active-site cysteine or histidine are viable.

Authors:  Jianlei Wang; Amy N Loveland; Lisa M Kattenhorn; Hidde L Ploegh; Wade Gibson
Journal:  J Virol       Date:  2006-06       Impact factor: 5.103

4.  The 65,000-Mr DNA-binding and virion trans-inducing proteins of herpes simplex virus type 1.

Authors:  H S Marsden; M E Campbell; L Haarr; M C Frame; D S Parris; M Murphy; R G Hope; M T Muller; C M Preston
Journal:  J Virol       Date:  1987-08       Impact factor: 5.103

5.  Identification of viral polypeptides involved in pseudorabies virus ribonucleotide reductase activity.

Authors:  E A Cohen; H Paradis; P Gaudreau; P Brazeau; Y Langelier
Journal:  J Virol       Date:  1987-06       Impact factor: 5.103

6.  Localization on the herpes simplex virus type 1 genome of a region encoding proteins involved in adsorption to the cellular receptor.

Authors:  N Langeland; A M Oyan; H S Marsden; A Cross; J C Glorioso; L J Moore; L Haarr
Journal:  J Virol       Date:  1990-03       Impact factor: 5.103

7.  Determination and analysis of the complete nucleotide sequence of human herpesvirus.

Authors:  J Nicholas
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

8.  An autophosphorylating but not transphosphorylating activity is associated with the unique N terminus of the herpes simplex virus type 1 ribonucleotide reductase large subunit.

Authors:  J Conner; J Cooper; J Furlong; J B Clements
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

9.  Induction of interleukin-6 in human retinal epithelial cells by an attenuated Herpes simplex virus vector requires viral replication and NFkappaB activation.

Authors:  Suping Cai; Curtis R Brandt
Journal:  Exp Eye Res       Date:  2007-12-03       Impact factor: 3.467

10.  Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions.

Authors:  J Nicholas; M E Martin
Journal:  J Virol       Date:  1994-02       Impact factor: 5.103
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