Literature DB >> 6319736

Unstable heterozygosity in a diploid region of herpes simplex virus DNA.

S L Varmuza, J R Smiley.   

Abstract

We have examined the behavior of a herpes simplex virus strain KOS isolate in which the two inverted repeats flanking the short segment of viral DNA differ in length by approximately 60 base pairs. We find that individual viral DNA molecules exist which contain the two distinguishable repeats, demonstrating that heterology between the repeats is tolerated. However, viruses heterozygous for the two different repeats are unstable, segregating both classes of homozygotes at a high frequency. We propose that this segregation is a consequence of the high-frequency recombination events which also result in genome segment inversion.

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Year:  1984        PMID： 6319736      PMCID： PMC255473     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  18 in total

1.  Orientation of herpes simplex virus type 1 immediate early mRNA's.

Authors:  J B Clements; J McLauchlan; D J McGeoch
Journal:  Nucleic Acids Res       Date:  1979-09-11       Impact factor: 16.971

2.  Separation and characterization of herpes simplex virus type 1 immediate-early mRNA's.

Authors:  R J Watson; C M Preston; J B Clements
Journal:  J Virol       Date:  1979-07       Impact factor: 5.103

3.  Structure of the joint region and the termini of the DNA of herpes simplex virus type 1.

Authors:  M J Wagner; W C Summers
Journal:  J Virol       Date:  1978-08       Impact factor: 5.103

4.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

5.  Nucleotide sequences of the joint between the L and S segments of herpes simplex virus types 1 and 2.

Authors:  A J Davison; N M Wilkie
Journal:  J Gen Virol       Date:  1981-08       Impact factor: 3.891

6.  Construction of a double-jointed herpes simplex viral DNA molecule: inverted repeats are required for segment inversion, and direct repeats promote deletions.

Authors:  J R Smiley; B S Fong; W C Leung
Journal:  Virology       Date:  1981-08       Impact factor: 3.616

7.  Molecular engineering of the herpes simplex virus genome: insertion of a second L-S junction into the genome causes additional genome inversions.

Authors:  E S Mocarski; L E Post; B Roizman
Journal:  Cell       Date:  1980-11       Impact factor: 41.582

8.  Molecular genetics of herpes simplex virus: the terminal a sequences of the L and S components are obligatorily identical and constitute a part of a structural gene mapping predominantly in the S component.

Authors:  D M Knipe; W T Ruyechan; R W Honess; B Roizman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

9.  Physical maps for Herpes simplex virus type 1 DNA for restriction endonucleases Hind III, Hpa-1, and X. bad.

Authors:  N M Wilkie
Journal:  J Virol       Date:  1976-10       Impact factor: 5.103

10.  Regulation of herpesvirus macromolecular synthesis: transcription-initiation sites and domains of alpha genes.

Authors:  S Mackem; B Roizman
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205
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  14 in total

1.  Recombination of the internal direct repeat element DR2 responsible for the fluidity of the a sequence of herpes simplex virus type 1.

Authors:  K Umene
Journal:  J Virol       Date:  1991-10       Impact factor: 5.103

2.  Insertion and deletion mutagenesis of the human cytomegalovirus genome.

Authors:  R R Spaete; E S Mocarski
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

3.  Novel rearrangements of herpes simplex virus DNA sequences resulting from duplication of a sequence within the unique region of the L component.

Authors:  K L Pogue-Geile; G T Lee; P G Spear
Journal:  J Virol       Date:  1985-02       Impact factor: 5.103

4.  Enhanced rate of conversion or recombination of markers within a region of unique sequence in the herpes simplex virus genome.

Authors:  K L Pogue-Geile; P G Spear
Journal:  J Virol       Date:  1986-05       Impact factor: 5.103

5.  Transition from a heterozygous to a homozygous state of a pair of loci in the inverted repeat sequences of the L component of the herpes simplex virus type 1 genome.

Authors:  K Umene
Journal:  J Virol       Date:  1987-04       Impact factor: 5.103

6.  Restriction endonucleases recognizing DNA sequences of four base pairs facilitate differentiation of herpes simplex virus type 1 strains.

Authors:  K Umene
Journal:  Arch Virol       Date:  1987       Impact factor: 2.574

7.  Cleavage in and around the DR1 element of the A sequence of herpes simplex virus type 1 relevant to the excision of DNA fragments with length corresponding to one and two units of the A sequence.

Authors:  K Umene
Journal:  J Virol       Date:  2001-07       Impact factor: 5.103

8.  Herpes simplex virus 1 reiterated S component sequences (c1) situated between the a sequence and alpha 4 gene are not essential for virus replication.

Authors:  J Hubenthal-Voss; B Roizman
Journal:  J Virol       Date:  1985-05       Impact factor: 5.103

9.  Retroviral insertional activation in a herpesvirus: transcriptional activation of US genes by an integrated long terminal repeat in a Marek's disease virus clone.

Authors:  D Jones; P Brunovskis; R Witter; H J Kung
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

10.  Requirement for double-strand breaks but not for specific DNA sequences in herpes simplex virus type 1 genome isomerization events.

Authors:  R T Sarisky; P C Weber
Journal:  J Virol       Date:  1994-01       Impact factor: 5.103
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