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Literature DB >> 6319478

Naloxone does not alter the effect of gamma aminobutyric acid derivative, baclofen, on GH release in man.

P Chiodera, R Volpi, V Coiro, L Barilli, G Rossi, E Roti.

Abstract

To evaluate the interaction between opioid peptides and GABAergic system in regulating GH secretion we administered 5 mg of baclofen, a GABA derivative, to eight normal male subjects. The results were compared to those obtained in the same subjects treated with naloxone (10 mg/2 h) plus baclofen. GH levels increased significantly above basal value either after baclofen and naloxone plus baclofen without any significant difference between GH responses during the two tests. It is suggested that the two substances do not act at the level of the same receptor site. The evaluation of a possible interaction between opioid peptides and GABAergic system on GH release requires further investigation.

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Year: 1983 PMID： 6319478 DOI： 10.1007/bf03347621

Source DB: PubMed Journal: J Endocrinol Invest ISSN： 0391-4097 Impact factor: 4.256

33 in total

1. Opiate receptor agonists as modulators of gamma-aminobutyric acid turnover in the nucleus caudatus, globus pallidus and substantia nigra of the rat.

Authors: F Moroni; D L Cheney; E Peralta; E Costa
Journal: J Pharmacol Exp Ther Date: 1978-12 Impact factor: 4.030

2. Receptor binding and pharmacological activity of opiates in the guinea-pig intestine.

Authors: I Creese; S H Snyder
Journal: J Pharmacol Exp Ther Date: 1975-07 Impact factor: 4.030

3. Stimulating effects of gamma-hydroxybutyrate on dopamine release from the caudate nucleus and the substantia nigra of the cat.

Authors: A Chéramy; A Nieoullon; J Glowinski
Journal: J Pharmacol Exp Ther Date: 1977-11 Impact factor: 4.030

4. The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

Authors: W R Martin; C G Eades; J A Thompson; R E Huppler; P E Gilbert
Journal: J Pharmacol Exp Ther Date: 1976-06 Impact factor: 4.030

5. Dopamine concentrations in the rat brain following injections into the substantia nigra of baclofen, gamma-aminobutyric acid, gamma-hydroxybutyric acid, apomorphine and amphetamine.

Authors: P H Kelly; K E Moore
Journal: Neuropharmacology Date: 1978-03 Impact factor: 5.250

6. The direction of opiodid agonists towards mu-, delta- and epsilon-receptors in the vas deferens of the mouse and the rat.

Authors: M Wüster; R Schulz; A Herz
Journal: Life Sci Date: 1980-07-14 Impact factor: 5.037

1. Low-dose baclofen therapy raised plasma insulin-like growth factor-1 concentrations, but not into the normal range in a predictable and sustained manner in men with chronic spinal cord injury.

Authors: William A Bauman; Michael F La Fountaine; Christopher M Cirnigliaro; Steven C Kirshblum; Ann M Spungen
Journal: J Spinal Cord Med Date: 2013-09 Impact factor: 1.985

1 in total

Naloxone does not alter the effect of gamma aminobutyric acid derivative, baclofen, on GH release in man.

1. Opiate receptor agonists as modulators of gamma-aminobutyric acid turnover in the nucleus caudatus, globus pallidus and substantia nigra of the rat.

2. Receptor binding and pharmacological activity of opiates in the guinea-pig intestine.

3. Stimulating effects of gamma-hydroxybutyrate on dopamine release from the caudate nucleus and the substantia nigra of the cat.

4. The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

5. Dopamine concentrations in the rat brain following injections into the substantia nigra of baclofen, gamma-aminobutyric acid, gamma-hydroxybutyric acid, apomorphine and amphetamine.

6. The direction of opiodid agonists towards mu-, delta- and epsilon-receptors in the vas deferens of the mouse and the rat.

7. Stimulatory effect of acute baclofen administration on human growth hormone secretion.

8. Mu and delta receptors: their role in analgesia in the differential effects of opioid peptides on analgesia.

9. Naloxone as a GABA antagonist: evidence from iontophoretic, receptor binding and convulsant studies.

10. Stimulatory effects of gamma-hydroxybutyric acid on growth hormone and prolactin release in humans.

1. Low-dose baclofen therapy raised plasma insulin-like growth factor-1 concentrations, but not into the normal range in a predictable and sustained manner in men with chronic spinal cord injury.