Literature DB >> 6318658

Effect of gentamicin treatment on adenylate cyclase and Na+, K+-ATPase activities in renal tissues of rats.

S F Queener, F C Luft, F G Hamel.   

Abstract

Gentamicin (20 mg/kg) treatment of male rats reduced Na+,K+-ATPase activity by 32% in renal cortical plasma membranes. In contrast, adenylate cyclase stimulation by isoproterenol or a guanyl nucleotide or both was enhanced by as much as twofold in glomeruli and in plasma membranes of gentamicin-treated rats. These effects of gentamicin are suggested to be related to the changes in renal phospholipid metabolism produced by the drug.

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Year:  1983        PMID： 6318658      PMCID： PMC185949          DOI： 10.1128/AAC.24.5.815

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Preparation and characterization of a hormone-responsive renal plasma membrane fraction.

Authors:  S J Marx; S A Fedak; G D Aurbach
Journal:  J Biol Chem       Date:  1972-11-10       Impact factor: 5.157

2.  A highly sensitive adenylate cyclase assay.

Authors:  Y Salomon; C Londos; M Rodbell
Journal:  Anal Biochem       Date:  1974-04       Impact factor: 3.365

3.  Analysis of sodium fluoride enhancement of calcitonin stimulation of renal cortical adenylate cyclase.

Authors:  S F Queener; J W Fleming; N H Bell
Journal:  J Biol Chem       Date:  1978-12-25       Impact factor: 5.157

4.  Inhibition of kidney lysosomal phospholipases A and C by aminoglycoside antibiotics: possible mechanism of aminoglycoside toxicity.

Authors:  K Y Hostetler; L B Hall
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

5.  Renal cortex ion composition and Na-K-ATPase activity in gentamicin nephrotoxicity.

Authors:  R E Cronin; K L Nix; E R Ferguson; P M Southern; W L Henrich
Journal:  Am J Physiol       Date:  1982-05

6.  Phosphatidylcholine-promoted interaction of the catalytic and regulatory proteins of adenylate cyclase.

Authors:  E M Ross
Journal:  J Biol Chem       Date:  1982-09-25       Impact factor: 5.157

7.  Gentamicin nephrotoxicity. II. Physiological, biochemical and morphological effects of prolonged administration to rats.

Authors:  F E Cuppage; K Setter; P Sullivan; E J Reitzes; A O Melnykovych
Journal:  Virchows Arch B Cell Pathol       Date:  1977-06-24

8.  Autoradiographic localization of [3H]gentamicin in the proximal renal tubules of mice.

Authors:  M J Kuhar; L L Mak; P S Lietman
Journal:  Antimicrob Agents Chemother       Date:  1979-01       Impact factor: 5.191

9.  Intact vesicles of canine cardiac sarcolemma: evidence from vectorial properties of Na+, K+-ATPase.

Authors:  H R Besch; L R Jones; A M Watanabe
Journal:  Circ Res       Date:  1976-10       Impact factor: 17.367

10.  Fatty acids as modulators of membrane functions: catecholamine-activated adenylate cyclase of the turkey erythrocyte.

Authors:  J Orly; M Schramm
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205
  10 in total

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