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Literature DB >> 6317895

Mouse mammary tumor virus: specific methylation patterns of proviral DNA in normal mouse tissues.

Abstract

The methylation state of endogenous mouse mammary tumor virus (MuMTV) proviral DNA was examined in normal mouse tissues. DNAs from various tissues were cleaved with the methylation-sensitive enzymes HhaI and HpaII and analyzed by Southern blotting. Tissue-specific MuMTV proviral DNA methylation patterns were found in the BALB/c, C3H, C57BL, GR/A, and GR-Mtv-2- mouse strains. MuMTV proviral DNA was hypomethylated in DNAs from the spleens and testes of all strains examined. The GR/A mouse strain, which was most thoroughly studied, also showed hypomethylation of MuMTV proviral DNA in bone marrow and placental tissues. Analysis of RNAs extracted from GR/A liver, mammary tumor, testes, placenta, and spleen tissues demonstrated that MuMTV proviral hypomethylation need not reflect significant proviral transcription.

Entities: Disease Species

Mesh：

Substances：
DNA, Viral
RNA, Viral

Year: 1984 PMID： 6317895 PMCID： PMC255425

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

33 in total

1. Genomic location of mouse mammary tumor virus proviral DNA in normal mouse tissue and in mammary tumors.

Authors: N E Hynes; B Groner; H Diggelmann; R Van Nie; R Michalides
Journal: Cold Spring Harb Symp Quant Biol Date: 1980

2. Chromosomal position effects determine transcriptional potential of integrated mammary tumor virus DNA.

Authors: S C Feinstein; S R Ross; K R Yamamoto
Journal: J Mol Biol Date: 1982-04-15 Impact factor: 5.469

3. Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure.

Authors: F C Kafatos; C W Jones; A Efstratiadis
Journal: Nucleic Acids Res Date: 1979-11-24 Impact factor: 16.971

4. Integration of the DNA of mouse mammary tumor virus in virus-infected normal and neoplastic tissue of the mouse.

Authors: J C Cohen; P R Shank; V L Morris; R Cardiff; H E Varmus
Journal: Cell Date: 1979-02 Impact factor: 41.582

5. Acquisition of proviral DNA of mouse mammary tumor virus in thymic leukemia cells from GR mice.

Authors: R Michalides; E Wagenaar; J Hilkens; J Hilgers; B Groner; N E Hynes
Journal: J Virol Date: 1982-09 Impact factor: 5.103

6. Integration of new endogenous mouse mammary tumor virus proviral DNA at common sites in the DNA of mammary tumors of C3Hf mice and hypomethylation of the endogenous mouse mammary tumor virus proviral DNA in C3Hf mammary tumors and spleens.

Authors: P R Etkind; N H Sarkar
Journal: J Virol Date: 1983-01 Impact factor: 5.103

7. Demethylation and expression of murine mammary tumor proviruses in mouse thymoma cell lines.

Authors: J J Mermod; S Bourgeois; N Defer; M Crépin
Journal: Proc Natl Acad Sci U S A Date: 1983-01 Impact factor: 11.205

8. Development of a mouse mammary tumor virus-negative mouse strain: a new system for the study of mammary carcinogenesis.

Authors: J C Cohen; V L Traina; T Breznik; M Gardner
Journal: J Virol Date: 1982-12 Impact factor: 5.103

9. Mouse mammary tumor virus proviral sequences congenital to C3H/Sm mice are differentially hypomethylated in chemically induced, virus-induced, and spontaneous mammary tumors.

Authors: W N Drohan; L E Benade; D E Graham; G H Smith
Journal: J Virol Date: 1982-09 Impact factor: 5.103

10. Methylation of milk-borne and genetically transmitted mouse mammary tumor virus proviral DNA.

Authors: J C Cohen
Journal: Cell Date: 1980-03 Impact factor: 41.582

17 in total

Review 1. Factors controlling the expression of mouse mammary tumour virus.

Authors: W H Günzburg; B Salmons
Journal: Biochem J Date: 1992-05-01 Impact factor: 3.857

2. Analysis of tissue-specific methylation patterns of mouse mammary tumor virus DNA by two-dimensional Southern blotting.

Authors: T G Fanning; W S Hu; R D Cardiff
Journal: J Virol Date: 1985-06 Impact factor: 5.103

3. Characterization of an endogenous retrovirus-repetitive DNA chimera in the mouse genome.

Authors: T G Fanning; D W Morris; R D Cardiff; H D Bradshaw
Journal: J Virol Date: 1985-03 Impact factor: 5.103

4. DNA methylation and transcriptional controls of proviral DNA in avian sarcoma virus-transformed mammalian cells.

Authors: F Catala
Journal: Nucleic Acids Res Date: 1986-03-25 Impact factor: 16.971

5. Visualization of clustered protocadherin neuronal self-recognition complexes.

Authors: Julia Brasch; Kerry M Goodman; Alex J Noble; Micah Rapp; Seetha Mannepalli; Fabiana Bahna; Venkata P Dandey; Tristan Bepler; Bonnie Berger; Tom Maniatis; Clinton S Potter; Bridget Carragher; Barry Honig; Lawrence Shapiro
Journal: Nature Date: 2019-04-10 Impact factor: 49.962

6. The mouse mammary tumor virus long terminal repeat directs expression in epithelial and lymphoid cells of different tissues in transgenic mice.

Authors: Y W Choi; D Henrard; I Lee; S R Ross
Journal: J Virol Date: 1987-10 Impact factor: 5.103

10. A transcriptionally defective long terminal repeat within an endogenous copy of mouse mammary tumor virus proviral DNA.

Authors: W L Kuo; L R Vilander; M Huang; D O Peterson
Journal: J Virol Date: 1988-07 Impact factor: 5.103