Literature DB >> 6294336

Development of a mouse mammary tumor virus-negative mouse strain: a new system for the study of mammary carcinogenesis.

J C Cohen, V L Traina, T Breznik, M Gardner.   

Abstract

All inbred strains of mice transmit one or more copies of mouse mammary tumor virus (MMTV) DNA integrated as proviral sequences. This complicates efforts to define viral-induced mammary carcinogenesis. Here we report the use of surgical nonlethal splenectomy in tissue typing mice and the development of an MMTV-negative mouse strain. The MMTV-negative strain allows study of the involvement of non-MMTV genes in mammary carcinogenesis. In addition, it can be used as a sterile background into which MMTV variants can be introduced. Through the techniques described here, mice containing single MMTV loci or specific combinations can be specially chosen and rapidly developed. In this manner, the oncogenecity of particular MMTV variants may be assessed.

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Year:  1982        PMID： 6294336      PMCID： PMC256346     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  8 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  Comparison of mouse mammary tumor virus-specific DNA in inbred, wild and Asian mice, and in tumors and normal organs from inbred mice.

Authors:  V L Morris; E Medeiros; G M Ringold; J M Bishop; H E Varmus
Journal:  J Mol Biol       Date:  1977-07       Impact factor: 5.469

Review 3.  Host-virus interactions in murine mammary carcinogenesis.

Authors:  P Bentvelzen
Journal:  Biochim Biophys Acta       Date:  1974-12-31

4.  X-ray intensifying screens greatly enhance the detection by autoradiography of the radioactive isotopes 32P and 125I.

Authors:  R Swanstrom; P R Shank
Journal:  Anal Biochem       Date:  1978-05       Impact factor: 3.365

5.  A membrane-filter technique for the detection of complementary DNA.

Authors:  D T Denhardt
Journal:  Biochem Biophys Res Commun       Date:  1966-06-13       Impact factor: 3.575

6.  Integration of the DNA of mouse mammary tumor virus in virus-infected normal and neoplastic tissue of the mouse.

Authors:  J C Cohen; P R Shank; V L Morris; R Cardiff; H E Varmus
Journal:  Cell       Date:  1979-02       Impact factor: 41.582

7.  Organization of mouse mammary tumor virus-specific DNA endogenous to BALB/c mice.

Authors:  J C Cohen; J E Majors; H E Varmus
Journal:  J Virol       Date:  1979-11       Impact factor: 5.103

8.  Genetic mapping of endogenous mouse mammary tumor viruses: locus characterization, segregation, and chromosomal distribution.

Authors:  V L Traina; B A Taylor; J C Cohen
Journal:  J Virol       Date:  1981-12       Impact factor: 5.103
  8 in total
  6 in total

1.  Analysis of tissue-specific methylation patterns of mouse mammary tumor virus DNA by two-dimensional Southern blotting.

Authors:  T G Fanning; W S Hu; R D Cardiff
Journal:  J Virol       Date:  1985-06       Impact factor: 5.103

2.  Transfer, by selective breeding, of the pathogenic Mtv-2 endogenous provirus from the GR strain to a wild mouse line free of endogenous and exogenous mouse mammary tumor virus.

Authors:  D W Morris; L J Young; M B Gardner; R D Cardiff
Journal:  J Virol       Date:  1986-05       Impact factor: 5.103

3.  Characterization, chromosome assignment, and segregation analysis of endogenous proviral units of mouse mammary tumor virus.

Authors:  G Peters; M Placzek; S Brookes; C Kozak; R Smith; C Dickson
Journal:  J Virol       Date:  1986-09       Impact factor: 5.103

4.  Isolation of a pathogenic clone of mouse mammary tumor virus.

Authors:  D W Morris; H D Bradshaw; H T Billy; R J Munn; R D Cardiff
Journal:  J Virol       Date:  1989-01       Impact factor: 5.103

5.  Mouse mammary tumor virus: specific methylation patterns of proviral DNA in normal mouse tissues.

Authors:  W S Hu; T G Fanning; R D Cardiff
Journal:  J Virol       Date:  1984-01       Impact factor: 5.103

6.  The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire.

Authors:  M T Scherer; L Ignatowicz; A Pullen; J Kappler; P Marrack
Journal:  J Exp Med       Date:  1995-11-01       Impact factor: 14.307
  6 in total

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