Literature DB >> 6315118

Responses of human skin to intradermal injection of leukotrienes C4, D4 and B4.

R D Camp, A A Coutts, M W Greaves, A B Kay, M J Walport.   

Abstract

The ability of intradermally injected leukotrienes C4 (LTC4), LTD4 and LTB4 to produce inflammatory changes in human skin alone and in combination with prostaglandin E2 (PGE2) has been investigated. LTC4 and D4 (0.012-0.38 nmol) caused dose-related erythema and wealing. No evidence of synergism between PGE2 and LTC4 or LTD4 was detected, although only single dose combinations were studied. LTB4 (0.15-1.5 nmol) caused areas of induration which persisted for more than 4 h and which showed perivascular neutrophil infiltrates on histological examination. Only slight synergism between PGE2 and LTB4 was found. It was concluded that these pro-inflammatory properties of LTC4, LTD4 and LTB4 are consistent with their proposed roles as mediators of inflammation in the skin and other tissues.

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Year:  1983        PMID： 6315118      PMCID： PMC2044991          DOI： 10.1111/j.1476-5381.1983.tb10721.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  17 in total

1.  Vascular reactions to histamine and compound 48/80 in human skin: suppression by a histamine H2-receptor blocking agent.

Authors:  R Marks; M W Greaves
Journal:  Br J Clin Pharmacol       Date:  1977-06       Impact factor: 4.335

2.  Control of vascular permeability by polymorphonuclear leukocytes in inflammation.

Authors:  C V Wedmore; T J Williams
Journal:  Nature       Date:  1981-02-19       Impact factor: 49.962

3.  Structural requirement for the action of leukotriene B4 on the guinea-pig lung:importance of double bond geometry in the 6, 8, 10-triene unit.

Authors:  P Sirois; S Roy; P Borgeat; S Picard; E J Corey
Journal:  Biochem Biophys Res Commun       Date:  1981-03-31       Impact factor: 3.575

4.  The effect of leukotrienes C4 and D4 on the microvasculature of guinea-pig skin.

Authors:  M J Peck; P J Piper; T J Williams
Journal:  Prostaglandins       Date:  1981-02

5.  Nomenclature for leukotrienes.

Authors:  B Samuelsson; S Hammarström
Journal:  Prostaglandins       Date:  1980-05

6.  Local effects of synthetic leukotrienes (LTC4, LTD4, LTE4, and LTB4) in human skin.

Authors:  N A Soter; R A Lewis; E J Corey; K F Austen
Journal:  J Invest Dermatol       Date:  1983-02       Impact factor: 8.551

7.  Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes.

Authors:  A W Ford-Hutchinson; M A Bray; M V Doig; M E Shipley; M J Smith
Journal:  Nature       Date:  1980-07-17       Impact factor: 49.962

8.  Chemokinetic activity of arachidonic and lipoxygenase products on leuocyctes of different species.

Authors:  R M Palmer; R J Stepney; G A Higgs; K E Eakins
Journal:  Prostaglandins       Date:  1980-08

9.  Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.

Authors:  L B Klickstein; C Shapleigh; E J Goetzl
Journal:  J Clin Invest       Date:  1980-11       Impact factor: 14.808

Review 10.  From slow reacting substance of anaphylaxis (SRS-A) to leukotriene D4 (LTD4).

Authors:  P Sirois; P Borgeat
Journal:  Int J Immunopharmacol       Date:  1980
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  55 in total

1.  15-hydroxyeicosatetraenoic acid (15-HETE) specifically inhibits the LTB4-induced skin response.

Authors:  T Ternowitz; P H Andersen; P Bjerring; K Fogh; J M Schröder; K Kragballe
Journal:  Arch Dermatol Res       Date:  1989       Impact factor: 3.017

2.  Cutaneous responses to 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) and 5,12-dihydroxyeicosatetraenoic acid (leukotriene B4) in psoriasis and normal human skin.

Authors:  P M Dowd; A K Black; P W Woollard; M W Greaves
Journal:  Arch Dermatol Res       Date:  1987       Impact factor: 3.017

3.  Leukotriene B4 and prostaglandin E2 mediate the inflammatory response of rabbit skin to intradermal arachidonic acid.

Authors:  D M Aked; S J Foster
Journal:  Br J Pharmacol       Date:  1987-11       Impact factor: 8.739

4.  Failure to detect deposition of complement and immunoglobulin in allergen-induced late-phase skin reaction in atopic subjects.

Authors:  A J Frew; A B Kay
Journal:  Clin Exp Immunol       Date:  1991-07       Impact factor: 4.330

5.  Tolfenamic acid inhibits leukotriene B4-induced chemotaxis of polymorphonuclear leukocytes in vitro.

Authors:  H Kankaanranta; E Moilanen; H Vapaatalo
Journal:  Inflammation       Date:  1991-04       Impact factor: 4.092

6.  The inflammatory response of rabbit skin to topical arachidonic acid and its pharmacological modulation.

Authors:  D Aked; S J Foster; A Howarth; M E McCormick; H C Potts
Journal:  Br J Pharmacol       Date:  1986-10       Impact factor: 8.739

7.  Effect of a leukotriene B4 receptor antagonist on leukotriene B4-induced neutrophil chemotaxis in cavine dermis.

Authors:  D J Fretland; D L Widomski; J M Zemaitis; S W Djurić; R L Shone
Journal:  Inflammation       Date:  1989-10       Impact factor: 4.092

8.  In vitro effects of leukotriene B4 (LTB4) on canine PMN effector function(s).

Authors:  D F Gruber; M M D'Alesandro; T L Walden
Journal:  Agents Actions       Date:  1989-11

9.  Ultrastructural analysis of leukocytes recruited into the guinea pig lung by LTB4 aerosol.

Authors:  A Shay; T Connolly; D N Smith; G L Crean
Journal:  Agents Actions       Date:  1989-06

10.  Lung responsiveness to antigen in sensitised mice of different strains.

Authors:  C Zuany-Amorim; M Pretolani; D Leduc; R Cordeiro; B B Vargaftig
Journal:  Agents Actions       Date:  1993
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