| Literature DB >> 6314195 |
Abstract
The effect of CGS 8216 (10 mg/kg) alone and in combination with the imidazodiazepine Ro 15-1788 (10 mg/kg) or ethyl-beta-carboline-3-carboxylate (beta-CCE 1 mg/kg) was tested in the social interaction test of anxiety. All 3 compounds were found to have an anxiogenic action. When Ro 15-1788 or beta-CCE was combined with CGS 8216, no mutual antagonism of the drugs' effects was observed. The failure of Ro 15-1788 to antagonize the anxiogenic action of CGS 8216 raises the possibility that CGS 8216 might be acting at a non-benzodiazepine site.Entities:
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Year: 1983 PMID： 6314195 DOI： 10.1016/0304-3940(83)90170-2
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046