Literature DB >> 6313447

A model of cell cycle control: sequential events regulated by growth factors.

E J O'Keefe, W J Pledger.   

Abstract

PDGF is a potent mitogen that initiates the proliferation of quiescent fibroblastic cells. EGF and somatomedin C (or insulin) can replace the requirement for plasma to function synergistically with PDGF to stimulate DNA synthesis. PDGF, EGF and somatomedin C control discrete cellular events in the cell cycle. Cyclic AMP can potentiate the effects of polypeptide mitogens. The down-regulation of EGF receptors by PDGF and cyclic AMP brings about a loss of the requirement for exogenous EGF. The transient treatment of density-arrested fibroblasts with PDGF allows better study of synergistic actions of PDGF and plasma-derived factors. These synergistic interactions are important to understand in determining how multiple growth factors regulate cellular proliferation.

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Year:  1983        PMID： 6313447     DOI： 10.1016/0303-7207(83)90147-8

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  16 in total

Review 1.  Heterotopic ossification: clinical and cellular aspects.

Authors:  J R Sawyer; M A Myers; R N Rosier; J E Puzas
Journal:  Calcif Tissue Int       Date:  1991-09       Impact factor: 4.333

2.  Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.

Authors:  E B Leof; J A Proper; A S Goustin; G D Shipley; P E DiCorleto; H L Moses
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

3.  Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.

Authors:  E A Clark; J A Ledbetter
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

4.  Isolation of an autocrine growth factor from hepatoma HTC-SR cells.

Authors:  P Ove; M L Coetzee; P Scalamogna; A Francavilla; T E Starzl
Journal:  J Cell Physiol       Date:  1987-05       Impact factor: 6.384

5.  Modulation of growth and function of human gingival fibroblasts by fibroblast-activating factor derived from Porphyromonas gingivalis W50.

Authors:  J Mihara; Y Miyazawa; S C Holt
Journal:  Infect Immun       Date:  1993-02       Impact factor: 3.441

6.  Inhibition of the mitogenic effects of plasma by a monoclonal antibody to somatomedin C.

Authors:  W E Russell; J J Van Wyk; W J Pledger
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

7.  Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines.

Authors:  D A Bronzert; P Pantazis; H N Antoniades; A Kasid; N Davidson; R B Dickson; M E Lippman
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

8.  Regulation of protein metabolism and DNA synthesis by fibroblast growth factor in BHK-21 cells.

Authors:  M Ross; F J Ballard
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857

9.  Growth-regulatory effects of glucagon, insulin, and epidermal growth factor in cultured hepatocytes. Temporal aspects and evidence for bidirectional control by cyclic AMP.

Authors:  T E Sand; G H Thoresen; M Refsnes; T Christoffersen
Journal:  Dig Dis Sci       Date:  1992-01       Impact factor: 3.199

10.  Combined effects of somatomedin-like growth factors with fibroblast growth factor or epidermal growth factor in DNA synthesis in rabbit chondrocytes.

Authors:  Y Hiraki; H Inoue; Y Kato; M Fukuya; F Suzuki
Journal:  Mol Cell Biochem       Date:  1987-08       Impact factor: 3.396
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