Literature DB >> 6310993

Inherited susceptibility to retrovirus-induced transformation of Gardner syndrome cells.

S Rasheed, J S Rhim, E J Gardner.   

Abstract

Skin fibroblasts from patients with Gardner syndrome (GS), those with familial polyposis coli (FPC), and spouse or unrelated controls were karyotyped and tested for various growth properties including susceptibility to transformation by viral or chemical agents. Our results indicated that based on the higher susceptibility to retrovirus-induced transformation and chromosomal aneuploidy, the GS and FPC cells could be distinguished from those of the general population with more than 70% accuracy. However, much work is in order before any biological assay can be used for clinical diagnosis of GS or FPC patients.

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Year:  1983        PMID： 6310993      PMCID： PMC1685818     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  26 in total

1.  Study of human rectal epithelial cells in vitro. III. RNA, protein, and DNA synthesis in polyps and adjacent mucosa.

Authors:  E E Deschner; M Lipkin
Journal:  J Natl Cancer Inst       Date:  1970-01       Impact factor: 13.506

2.  Proceedings: Colon cancer and bacterial metabolism in familial polyposis.

Authors:  B S Drasar; E S Bone; M J Hill; C G Marks
Journal:  Gut       Date:  1975-10       Impact factor: 23.059

3.  Phenotypic markers in human skin fibroblasts as possible diagnostic indices of hereditary adenomatosis of the colon and rectum.

Authors:  L Kopelovich
Journal:  Cancer       Date:  1977-11       Impact factor: 6.860

4.  Induction of chromosome crossbanding by treating cells with chemical agents before fixation.

Authors:  T C Hsu; S Pathak; D A Shafer
Journal:  Exp Cell Res       Date:  1973-06       Impact factor: 3.905

5.  Tetraploid fibroblasts and familial polyposis coli.

Authors:  J D Delhanty; M B Pritchard; H J Bussey; B C Morson
Journal:  Lancet       Date:  1980-06-21       Impact factor: 79.321

6.  The Gardner syndrome: a cell culture study on kindred 109.

Authors:  B S Danes; E J Gardner
Journal:  J Med Genet       Date:  1978-10       Impact factor: 6.318

7.  Growth abnormalities of cultured human skin fibroblasts derived from individuals with hereditary adenomatosis of the colon and rectum.

Authors:  L Pfeffer; M Lipkin; O Stutman; L Kopelovich
Journal:  J Cell Physiol       Date:  1976-09       Impact factor: 6.384

8.  Fecal bile acids and neutral sterols in patients with familial polyposis.

Authors:  B S Reddy; A Mastromarino; C Gustafson; M Lipkin; E L Wynder
Journal:  Cancer       Date:  1976-10       Impact factor: 6.860

9.  Differential genetic susceptibility of cultured human skin fibroblasts to transformation by Kirsten murine sarcoma virus.

Authors:  L M Pfeffer; L Kopelovich
Journal:  Cell       Date:  1977-02       Impact factor: 41.582

10.  Tumor promoter induces loss of anchorage dependence in human skin fibroblasts from individuals genetically predisposed to cancer.

Authors:  L Kopelovich; N E Bias
Journal:  Exp Cell Biol       Date:  1980
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  4 in total

1.  Viral transformation of skin fibroblasts from persons affected with neurofibromatosis.

Authors:  J W Frankel; P Bidot
Journal:  Am J Hum Genet       Date:  1984-07       Impact factor: 11.025

2.  Induction of tumorigenesis and chromosomal abnormalities in human amniocytes infected with simian virus 40 and Kirsten sarcoma virus.

Authors:  K H Walen; P Arnstein
Journal:  In Vitro Cell Dev Biol       Date:  1986-02

3.  Retrovirus-induced osteopetrosis in mice. Ultrastructural evidence of early virus production in osteoblasts and osteocytes.

Authors:  A B Murray; J Schmidt; L Rieke
Journal:  Am J Pathol       Date:  1986-08       Impact factor: 4.307

4.  Human c-fos oncogene mapped within chromosomal region 14q21----q31.

Authors:  P E Barker; M Rabin; M Watson; W R Breg; F H Ruddle; I M Verma
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205
  4 in total

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