Literature DB >> 3017117

Retrovirus-induced osteopetrosis in mice. Ultrastructural evidence of early virus production in osteoblasts and osteocytes.

A B Murray, J Schmidt, L Rieke.   

Abstract

Newborn female strain NMRI mice were given injections of a mouse retrovirus (OA MuLV) known to induce osteopetrosis, osteoma, and lymphoma. Femur metaphyses and lumbar vertebrae were investigated ultrastructurally 3 d, 7 d and 28 d after infection. Budding, immature and mature virus was observed associated with osteoblasts and osteocytes, but not with osteoclasts or chondrocytes, 28 d after infection with the virus. No production of virus particles was observed in bone-tissue in mock-treated controls. Thus, the primary target cell for OA virus in bone appears to belong to the osteoblastic/osteocytic cell lineage.

Entities:  

Mesh：

Year:  1986        PMID： 3017117      PMCID： PMC1888303     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  11 in total

Review 1.  Virus diseases of bone. Do they exist? The Neuhauser Lecture.

Authors:  F N Silverman
Journal:  AJR Am J Roentgenol       Date:  1976-04       Impact factor: 3.959

Review 2.  A review of inherited osteopetrosis in the mouse. Man and other mammals also considered.

Authors:  H M Murphy
Journal:  Clin Orthop Relat Res       Date:  1969 Jul-Aug       Impact factor: 4.176

3.  Role of osteoblasts in hormonal control of bone resorption--a hypothesis.

Authors:  G A Rodan; T J Martin
Journal:  Calcif Tissue Int       Date:  1981       Impact factor: 4.333

4.  Electron microscopy of avian osteopetrosis induced by retrovirus MAV.2-O.

Authors:  R M Frank; R M Franklin
Journal:  Calcif Tissue Int       Date:  1982-07       Impact factor: 4.333

5.  Bone tissue in Paget's disease of bone. Ultrastructure and Immunocytology.

Authors:  A Rebel; M Basle; A Pouplard; K Malkani; R Filmon; A Lepatezour
Journal:  Arthritis Rheum       Date:  1980-10

6.  Activation of endogenous C-type retroviral genomes by internal alpha-irradiation of mice with 224Radium.

Authors:  J Schmidt; V Erfle; W A Müller
Journal:  Radiat Environ Biophys       Date:  1985       Impact factor: 1.925

7.  Oncogenic retrovirus from spontaneous murine osteomas. II. Molecular cloning and genomic characterization.

Authors:  C Leib-Mösch; J Schmidt; M Etzerodt; F S Pedersen; R Hehlmann; V Erfle
Journal:  Virology       Date:  1986-04-15       Impact factor: 3.616

8.  Inherited susceptibility to retrovirus-induced transformation of Gardner syndrome cells.

Authors:  S Rasheed; J S Rhim; E J Gardner
Journal:  Am J Hum Genet       Date:  1983-09       Impact factor: 11.025

9.  Oncogenic retrovirus from spontaneous murine osteomas. I. Isolation and biological characterization.

Authors:  J Schmidt; V Erfle; F S Pedersen; H Rohmer; H Schetters; K H Marquart; A Luz
Journal:  J Gen Virol       Date:  1984-12       Impact factor: 3.891

10.  Osteoclast populations in congenital osteopetrosis: additional evidence of heterogeneity.

Authors:  C R Marks; M F Seifert; S C Marks
Journal:  Metab Bone Dis Relat Res       Date:  1984
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  5 in total

1.  Beta cell expression of endogenous xenotropic retrovirus distinguishes diabetes-susceptible NOD/Lt from resistant NON/Lt mice.

Authors:  H R Gaskins; M Prochazka; K Hamaguchi; D V Serreze; E H Leiter
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

2.  Retrovirus-induced osteopetrosis in mice. Effects of viral infection on osteogenic differentiation in skeletoblast cell cultures.

Authors:  J Schmidt; M Casser-Bette; A B Murray; A Luz; V Erfle
Journal:  Am J Pathol       Date:  1987-12       Impact factor: 4.307

3.  Evidence for an osteoblast-activating factor in a patient with peripheral T-cell lymphoma and osteosclerosis.

Authors:  M Hüfner; H Döhner; J Schmidt; P Möller; A D Ho; W Hunstein
Journal:  Klin Wochenschr       Date:  1989-04-03

4.  Onset and dynamics of osteosclerosis in mice induced by Reilly-Finkel-Biskis (RFB) murine leukemia virus. Increase in bone mass precedes lymphomagenesis.

Authors:  J Schmidt; K Lumniczky; B D Tzschaschel; H L Guenther; A Luz; S Riemann; W Gimbel; V Erfle; R G Erben
Journal:  Am J Pathol       Date:  1999-08       Impact factor: 4.307

5.  Molecular cloning of osteoma-inducing replication-competent murine leukemia viruses from the RFB osteoma virus stock.

Authors:  L Pedersen; W Behnisch; J Schmidt; A Luz; F S Pedersen; V Erfle; P G Strauss
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103
  5 in total

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