Literature DB >> 6310561

Regulation of phosphorylation of proteins I, IIIa, and IIIb in rat neurohypophysis in vitro by electrical stimulation and by neuroactive agents.

K Tsou, P Greengard.   

Abstract

The state of phosphorylation of proteins I, IIIa, and IIIb--neuron-specific phosphoproteins--was studied in neurosecretory endings of the neurohypophysis in vitro. Brief periods (a few seconds) of electrical stimulation caused large increases in the state of phosphorylation of all three proteins. The three proteins were dephosphorylated within 1 min after termination of the stimulation. High potassium, 8-bromo-cAMP, and dopamine also stimulated the phosphorylation of the three proteins. The effect of dopamine was blocked by the dopamine antagonist fluphenazine. Peptide mapping of protein I revealed that electrical stimulation or high potassium increased the state of phosphorylation of two regions of the molecule, whereas 8-bromo-cAMP and dopamine increased the state of phosphorylation of only one of these regions.

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Year:  1982        PMID： 6310561      PMCID： PMC347055          DOI： 10.1073/pnas.79.19.6075

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

1.  Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

Authors:  D W Cleveland; S G Fischer; M W Kirschner; U K Laemmli
Journal:  J Biol Chem       Date:  1977-02-10       Impact factor: 5.157

2.  Organization and ultrastructural identification of the catecholamine nerve terminals in the neural lobe and pars intermedia of the rat pituitary.

Authors:  H G Baumgarten; A Björklund; A F Holstein; A Nobin
Journal:  Z Zellforsch Mikrosk Anat       Date:  1972

3.  The organization of tubero-hypophyseal and reticulo-infundibular catecholamine neuron systems in the rat brain.

Authors:  A Björklund; R Y Moore; A Nobin; U Stenevi
Journal:  Brain Res       Date:  1973-03-15       Impact factor: 3.252

4.  Depolarizing agents and cyclic nucleotides regulate the phosphorylation of specific neuronal proteins in rat cerebral cortex slices.

Authors:  J Forn; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

5.  Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium.

Authors:  W B Huttner; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

6.  Differential phosphorylation of multiple sites in purified protein I by cyclic AMP-dependent and calcium-dependent protein kinases.

Authors:  W B Huttner; L J DeGennaro; P Greengard
Journal:  J Biol Chem       Date:  1981-02-10       Impact factor: 5.157

7.  Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. I. Solubilization, purification, and some properties of an endogenous phosphoprotein.

Authors:  T Ueda; P Greengard
Journal:  J Biol Chem       Date:  1977-07-25       Impact factor: 5.157

8.  Immunocytochemical localization, in synapses, of protein I, an endogenous substrate for protein kinases in mammalian brain.

Authors:  F E Bloom; T Ueda; E Battenberg; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

9.  Widespread distribution of protein I in the central and peripheral nervous systems.

Authors:  P De Camilli; T Ueda; F E Bloom; E Battenberg; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

10.  Subcellular distribution in cerebral cortex of two proteins phosphorylated by a cAMP-dependent protein kinase.

Authors:  T Ueda; P Greengard; K Berzins; R S Cohen; F Blomberg; D J Grab; P Siekevitz
Journal:  J Cell Biol       Date:  1979-11       Impact factor: 10.539
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  8 in total

1.  Activation of the multifunctional Ca2+/calmodulin-dependent protein kinase by autophosphorylation: ATP modulates production of an autonomous enzyme.

Authors:  L L Lou; S J Lloyd; H Schulman
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

Review 2.  A molecular description of nerve terminal function.

Authors:  L F Reichardt; R B Kelly
Journal:  Annu Rev Biochem       Date:  1983       Impact factor: 23.643

Review 3.  Neuronal phosphoproteins. Mediators of signal transduction.

Authors:  P Greengard
Journal:  Mol Neurobiol       Date:  1987 Spring-Summer       Impact factor: 5.590

4.  Norepinephrine and isoproterenol increase the phosphorylation of synapsin I and synapsin II in dentate slices of young but not aged Fisher 344 rats.

Authors:  K D Parfitt; B J Hoffer; M D Browning
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

5.  Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse.

Authors:  R Llinás; T L McGuinness; C S Leonard; M Sugimori; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

6.  Cholinergic regulation of protein phosphorylation in bovine adrenal chromaffin cells.

Authors:  J W Haycock; M D Browning; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

7.  Modulation by fenoldopam (SKF 82526) and bromocriptine of the electrically evoked release of vasopressin from the rat neurohypophysis. Effects of dopamine depletion.

Authors:  K Racké; J Meuresch; B Trapp; E Muscholl
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-04       Impact factor: 3.000

Review 8.  Effects of nicotine on DARPP-32 and CaMKII signaling relevant to addiction.

Authors:  Angela M Lee; Marina R Picciotto
Journal:  Adv Pharmacol       Date:  2020-10-06
  8 in total

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