| Literature DB >> 6308570 |
J J Hyldig-Nielsen, L Schenning, U Hammerling, E Widmark, E Heldin, P Lind, B Servenius, T Lund, R Flavell, J S Lee, J Trowsdale, P H Schreier, F Zablitzky, D Larhammar, P A Peterson, L Rask.
Abstract
We have isolated and sequenced the complete murine I-E alpha immune response gene of the H-2db haplotype. The I-E alpha d gene consists of 5300 basepairs and is organized into five or possibly six exons that correspond to different domains of the alpha chain. The amino acid sequence deduced from the I-E alpha gene shows 75% homology to its human counterpart, the HLA-DR alpha chain. The absence of I-E antigen in H-2 mice is due to lack of E alpha chain synthesis. We show here that this defect is caused by a deletion in the 5' end of the I-E alpha b gene.Entities:
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Year: 1983 PMID： 6308570 PMCID： PMC326237 DOI： 10.1093/nar/11.15.5055
Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971