Literature DB >> 6307837

Wilson's disease and hepatocellular carcinoma: possible protective role of copper.

M L Wilkinson, B Portmann, R Williams.   

Abstract

A male patient with Wilson's disease developed a hepatocellular carcinoma after treatment for nine years with D-penicillamine. Examination at necropsy showed that excess liver copper had been effectively removed. As copper has been shown to protect against chemically induced hepatocellular carcinoma in rats, this may be the reason for the extreme rarity of hepatocellular carcinoma in patients with Wilson's disease and possibly in other liver diseases with hepatic copper overload.

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Year:  1983        PMID： 6307837      PMCID： PMC1420230          DOI： 10.1136/gut.24.8.767

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  12 in total

1.  Hepatolenticular degeneration (Wilson's disease) and juvenile cirrhosis in the same family.

Authors:  T LYGREN
Journal:  Lancet       Date:  1959-02-07       Impact factor: 79.321

2.  [A case of Wilson's disease with hepatoma (author's transl)].

Authors:  K Kamakura; S Kimura; S Igarashi; K Fujiwara; O Toshitsugu
Journal:  Nihon Naika Gakkai Zasshi       Date:  1975-03-10

3.  Effect of copper on hepatic tumors produced by 3-methyl-4-dimethylaminoazobenzene.

Authors:  E PEDRERO; F L KOZELKA
Journal:  AMA Arch Pathol       Date:  1951-11

4.  Hepatocellular carcinoma in Great Britain: influence of age, sex, HBsAg status, and aetiology of underlying cirrhosis.

Authors:  P J Johnson; N Krasner; B Portmann; A L Eddleston; R Williams
Journal:  Gut       Date:  1978-11       Impact factor: 23.059

5.  The inhibitory effect of copper on DL-ethionine carcinogenesis in rats.

Authors:  Y Kamamoto; S Makiura; S Sugihara; Y Hiasa; M Arai
Journal:  Cancer Res       Date:  1973-05       Impact factor: 12.701

Review 6.  The physiology of copper in man and its relation to Wilson's disease.

Authors:  J M Walshe
Journal:  Brain       Date:  1967-03       Impact factor: 13.501

7.  Clinicopathologic features of the syndrome of primary sclerosing cholangitis.

Authors:  R H Wiesner; N F LaRusso
Journal:  Gastroenterology       Date:  1980-08       Impact factor: 22.682

8.  Hepatocellular carcinoma in primary biliary cirrhosis: report of four cases.

Authors:  N Krasner; P J Johnson; B Portmann; G Watkinson; R N Macsween; R Williams
Journal:  Gut       Date:  1979-03       Impact factor: 23.059

9.  Histological demonstration and frequency of intrahepatocytic copper in patients suffering from alcoholic liver disease.

Authors:  P A Berresford; J P Sunter; V Harrison; M Lesna
Journal:  Histopathology       Date:  1980-11       Impact factor: 5.087

10.  The effect of copper acetate on p-dimethylaminoazobenzene carcinogenesis in the rat.

Authors:  J S HOWELL
Journal:  Br J Cancer       Date:  1958-12       Impact factor: 7.640
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  12 in total

1.  Two unusual cases with Wilson's disease: hepatoma and fulminant hepatitis treated with plasma exchange.

Authors:  Musa Aydinli; Ozgur Harmanci; Osman Ersoy; Arzu T Iskit; Osman Ozcebe; Osman Abbasoglu; Yusuf Bayraktar
Journal:  J Natl Med Assoc       Date:  2006-12       Impact factor: 1.798

2.  Consequences of copper accumulation in the livers of the Atp7b-/- (Wilson disease gene) knockout mice.

Authors:  Dominik Huster; Milton J Finegold; Clinton T Morgan; Jason L Burkhead; Randal Nixon; Scott M Vanderwerf; Conrad T Gilliam; Svetlana Lutsenko
Journal:  Am J Pathol       Date:  2006-02       Impact factor: 4.307

3.  Occurrence of hepatocellular carcinoma in chronic viral hepatitis.

Authors:  M Omata; S Takano
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333

4.  Wilson disease and hepatocellular carcinoma.

Authors:  Ruliang Xu; Cristina H Hajdu
Journal:  Gastroenterol Hepatol (N Y)       Date:  2008-06

Review 5.  Molecular imaging and therapy targeting copper metabolism in hepatocellular carcinoma.

Authors:  Jason Wachsmann; Fangyu Peng
Journal:  World J Gastroenterol       Date:  2016-01-07       Impact factor: 5.742

Review 6.  Insights into the pathogenesis and treatment of cancer from inborn errors of metabolism.

Authors:  Ayelet Erez; Oleg A Shchelochkov; Sharon E Plon; Fernando Scaglia; Brendan Lee
Journal:  Am J Hum Genet       Date:  2011-04-08       Impact factor: 11.025

7.  Wilson's disease-cause of mortality in 164 patients during 1992-2003 observation period.

Authors:  A Członkowska; B Tarnacka; T Litwin; J Gajda; M Rodo
Journal:  J Neurol       Date:  2005-03-02       Impact factor: 4.849

8.  Hepatocellular carcinoma in a non-cirrhotic patient with Wilson's disease.

Authors:  Raphael Thattil; Jean-François Dufour
Journal:  World J Gastroenterol       Date:  2013-04-07       Impact factor: 5.742

9.  Primary hepatocellular carcinoma associated with Wilson's disease in a young woman.

Authors:  R Guan; C J Oon; P K Wong; W C Foong; A Wee
Journal:  Postgrad Med J       Date:  1985-04       Impact factor: 2.401

10.  Intrahepatic cholangiocarcinoma in a patient with Wilson's disease: a case report.

Authors:  Yosuke Mukai; Hiroshi Wada; Hidetoshi Eguchi; Daisaku Yamada; Tadafumi Asaoka; Takehiro Noda; Koichi Kawamoto; Kunihito Gotoh; Yutaka Takeda; Masahiro Tanemura; Koji Umeshita; Yumiko Hori; Eiichi Morii; Yuichiro Doki; Masaki Mori
Journal:  Surg Case Rep       Date:  2016-03-23
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