| Literature DB >> 6306672 |
D J Giron, S J Cohen, S P Lyons, C H Wharton, D R Cerutis.
Abstract
The diabetogenic variant of encephalomyocarditis virus (EMC-D) induces a diabetes-like syndrome in certain strains of mice. A study was done to determine if virus-induced diabetes could be prevented by interferon (IFN). It was found that the production of diabetes by EMC-D was blocked by either IFN beta or a variety of IFN-inducers in SWR/J, but not ICR Swiss mice. The replication of EMC-D in cell culture was inhibited by IFN beta. It is concluded that the response of pancreatic beta cells to the protective effect of IFN, is probably under genetic control.Entities:
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Year: 1983 PMID： 6306672 DOI： 10.3181/00379727-173-41651
Source DB: PubMed Journal: Proc Soc Exp Biol Med ISSN： 0037-9727