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Literature DB >> 6306278

Specific proteolytic fragmentation of p60v-src in transformed cell lysates.

Abstract

Work involving the transforming protein, p60v-src, of Rous sarcoma virus has resulted in the extensive characterization of its protein structure and associated phosphotransferase activity. However, in many investigations proteolytic fragments (principally p52v-src) of the src protein are actually studied. Here, we emphasize potential problems in the interpretation of experimental results in which the proteolytic fragmentation of p60v-src may be involved and offer several means for the complete prevention of this p60v-src degradation.

Entities: Gene Species

Mesh：

Substances：

Year: 1983 PMID： 6306278 PMCID： PMC255245

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

23 in total

1. The src gene product of transformed and morphologically reverted ASV-infected mammalian cells.

Authors: M S Collett; J S Brugge; R L Erikson; A F Lau; R A Krzyzek; A J Faras
Journal: Nature Date: 1979-09-20 Impact factor: 49.962

2. Immunological identification of two adenovirus 2-induced early proteins possibly involved in cell transformation.

Authors: Z Gilead; Y H Jeng; W S Wold; K Sugawara; H M Rho; M L Harter; M Green
Journal: Nature Date: 1976-11-18 Impact factor: 49.962

3. Identification of a transformation-specific antigen induced by an avian sarcoma virus.

Authors: J S Brugge; R L Erikson
Journal: Nature Date: 1977-09-22 Impact factor: 49.962

4. Evidence that the avian sarcoma virus transforming gene product is a cyclic AMP-independent protein kinase.

Authors: R L Erikson; M S Collett; E Erikson; A F Purchio
Journal: Proc Natl Acad Sci U S A Date: 1979-12 Impact factor: 11.205

5. Protein kinase activity associated with the avian sarcoma virus src gene product.

Authors: M S Collett; R L Erikson
Journal: Proc Natl Acad Sci U S A Date: 1978-04 Impact factor: 11.205

6. Identification of a polypeptide encoded by the avian sarcoma virus src gene.

Authors: A F Purchio; E Erikson; J S Brugge; R L Erikson
Journal: Proc Natl Acad Sci U S A Date: 1978-03 Impact factor: 11.205

7. Evidence that the src gene product of Rous sarcoma virus is membrane associated.

Authors: J G Krueger; E Wang; A R Goldberg
Journal: Virology Date: 1980-02 Impact factor: 3.616

8. Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein.

Authors: A D Levinson; H Oppermann; L Levintow; H E Varmus; J M Bishop
Journal: Cell Date: 1978-10 Impact factor: 41.582

9. Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate.

Authors: J P Chamberlain
Journal: Anal Biochem Date: 1979-09-15 Impact factor: 3.365

10. Avian sarcoma virus-transforming protein, pp60src shows protein kinase activity specific for tyrosine.

Authors: M S Collett; A F Purchio; R L Erikson
Journal: Nature Date: 1980-05-15 Impact factor: 49.962

7 in total

1. Forms of pp60v-src isolated from Rous sarcoma virus-transformed cells.

Authors: M S Collett; S K Belzer
Journal: J Virol Date: 1987-05 Impact factor: 5.103

2. Characterization of pp60src phosphorylation in vitro in Rous sarcoma virus-transformed cell membranes.

Authors: M D Resh; R L Erikson
Journal: Mol Cell Biol Date: 1985-05 Impact factor: 4.272

3. N-terminal deletions in Rous sarcoma virus p60src: effects on tyrosine kinase and biological activities and on recombination in tissue culture with the cellular src gene.

Authors: F R Cross; E A Garber; H Hanafusa
Journal: Mol Cell Biol Date: 1985-10 Impact factor: 4.272