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Literature DB >> 230504

Evidence that the avian sarcoma virus transforming gene product is a cyclic AMP-independent protein kinase.

R L Erikson, M S Collett, E Erikson, A F Purchio.

Abstract

The avian sarcoma virus transforming gene product pp60src has been partially purified by using ion exchange or immunoaffinity chromatography. These preparations contain a cyclic AMP-independent protein kinase activity capable of transferring radiolabel from [gamma-32P]ATP to immune rabbit IgG, casein, and the heavy chain purified from normal rabbit IgG. The casein kinase activity is specifically inhibited by anti-pp60src IgG. Comparison of the pp60src-protein kinase isolated from cells transformed by a wild-type ASV or by an ASV temperature-sensitive transformation mutant revealed that the latter product had a half-life of 3 min at 41 degrees C whereas that of the wild-type product was 20 min.

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Year: 1979 PMID： 230504 PMCID： PMC411843 DOI： 10.1073/pnas.76.12.6260

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

15 in total

1. Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.

Authors: S W Kessler
Journal: J Immunol Date: 1975-12 Impact factor: 5.422

6. Intracellular localization and processing of pp60v-src proteins expressed by two distinct temperature-sensitive mutants of Rous sarcoma virus.

Authors: A W Stoker; S Kellie; J A Wyke
Journal: J Virol Date: 1986-06 Impact factor: 5.103

7. Phosphorylation in vitro of Escherichia coli-produced 235R and 266R tumor antigens encoded by human adenovirus type 12 early transformation region 1A.

Authors: L A Lucher; P M Loewenstein; M Green
Journal: J Virol Date: 1985-10 Impact factor: 5.103

8. Oncogenes and human cancer--a surgeon's perspective.

Authors: N I Markham
Journal: Ann R Coll Surg Engl Date: 1985-09 Impact factor: 1.891

9. Decrease of tyrosine-O-sulfate-containing proteins found in rat fibroblasts infected with Rous sarcoma virus or Fujinami sarcoma virus.

Authors: M C Liu; F Lipmann
Journal: Proc Natl Acad Sci U S A Date: 1984-06 Impact factor: 11.205

10. Interaction between the Rous sarcoma virus transforming protein and two cellular phosphoproteins: analysis of the turnover and distribution of this complex.

Authors: J Brugge; W Yonemoto; D Darrow
Journal: Mol Cell Biol Date: 1983-01 Impact factor: 4.272

Evidence that the avian sarcoma virus transforming gene product is a cyclic AMP-independent protein kinase.

1. Rapid isolation of antigens from cells with a staphylococcal protein A-antibody adsorbent: parameters of the interaction of antibody-antigen complexes with protein A.

2. In vitro synthesis of a functional avian sarcoma virus transforming-gene product.

3. Identification of a transformation-specific antigen induced by an avian sarcoma virus.

4. Peptide analysis of the transformation-specific antigen from avian sarcoma virus-transformed cells.

5. Protein kinase activity associated with the avian sarcoma virus src gene product.

6. Identification of a polypeptide encoded by the avian sarcoma virus src gene.

Review 7. Phosphorylation-dephosphorylation of enzymes.

8. Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein.

9. Product of in vitro translation of the Rous sarcoma virus src gene has protein kinase activity.

10. Properties of mammalian cells transformed by temperature-sensitive mutants of avian sarcoma virus.

Review 1. Structure and function of tyrosine kinase receptors.

2. Forms of pp60v-src isolated from Rous sarcoma virus-transformed cells.

3. In vivo effect of sodium orthovanadate on pp60c-src kinase.

4. Low level of cellular protein phosphorylation by nontransforming overproduced p60c-src.

5. Purification of the Rous sarcoma virus src kinase by casein-agarose and tyrosine-agarose affinity chromatography.

6. Intracellular localization and processing of pp60v-src proteins expressed by two distinct temperature-sensitive mutants of Rous sarcoma virus.

7. Phosphorylation in vitro of Escherichia coli-produced 235R and 266R tumor antigens encoded by human adenovirus type 12 early transformation region 1A.

8. Oncogenes and human cancer--a surgeon's perspective.

9. Decrease of tyrosine-O-sulfate-containing proteins found in rat fibroblasts infected with Rous sarcoma virus or Fujinami sarcoma virus.

10. Interaction between the Rous sarcoma virus transforming protein and two cellular phosphoproteins: analysis of the turnover and distribution of this complex.