Literature DB >> 6304878

Simple repeat array in Epstein-Barr virus DNA encodes part of the Epstein-Barr nuclear antigen.

K Hennessy, M Heller, V van Santen, E Kieff.   

Abstract

The size of the Epstein-Barr virus (EBV) nuclear antigen (EBNA) in cells infected with different EBV isolates varies directly with the size of the EBV triplet repeat array, IR3. The isolate with the largest IR3 fragment has approximately 170 more codons than the isolates with the smallest IR3 fragment; it encodes an EBNA which is approximately 17,000 daltons larger than the smallest EBNA. The EBV IR3 encodes part of a 2-kilobase exon of a latently infected cell messenger RNA which must be translated into a repetitive amino acid domain of EBNA.

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Year:  1983        PMID： 6304878     DOI： 10.1126/science.6304878

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  62 in total

1.  Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cells.

Authors:  J L Yates; N Guan
Journal:  J Virol       Date:  1991-01       Impact factor: 5.103

2.  Expression of the Epstein-Barr virus nuclear protein 2 in rodent cells.

Authors:  T Dambaugh; F Wang; K Hennessy; E Woodland; A Rickinson; E Kieff
Journal:  J Virol       Date:  1986-08       Impact factor: 5.103

3.  Levels of Epstein-Barr virus DNA in lymphoblastoid cell lines are correlated with frequencies of spontaneous lytic growth but not with levels of expression of EBNA-1, EBNA-2, or latent membrane protein.

Authors:  S Metzenberg
Journal:  J Virol       Date:  1990-01       Impact factor: 5.103

4.  Stable transfection of Epstein-Barr virus (EBV) nuclear antigen 2 in lymphoma cells containing the EBV P3HR1 genome induces expression of B-cell activation molecules CD21 and CD23.

Authors:  M Cordier; A Calender; M Billaud; U Zimber; G Rousselet; O Pavlish; J Banchereau; T Tursz; G Bornkamm; G M Lenoir
Journal:  J Virol       Date:  1990-03       Impact factor: 5.103

5.  Transcription of the Epstein-Barr virus genome during latency in growth-transformed lymphocytes.

Authors:  J Sample; E Kieff
Journal:  J Virol       Date:  1990-04       Impact factor: 5.103

6.  Molecular genetic analysis of lymphoid tumors arising after organ transplantation.

Authors:  J Locker; M Nalesnik
Journal:  Am J Pathol       Date:  1989-12       Impact factor: 4.307

7.  Molecular characterization and clinical use of a polymorphic tandem repeat in an intron of the human alanine:glyoxylate aminotransferase gene.

Authors:  C J Danpure; G M Birdsey; G Rumsby; M J Lumb; P E Purdue; J Allsop
Journal:  Hum Genet       Date:  1994-07       Impact factor: 4.132

8.  The Epstein-Barr virus EBNA-2 gene in oral hairy leukoplakia: strain variation, genetic recombination, and transcriptional expression.

Authors:  D M Walling; A G Perkins; J Webster-Cyriaque; L Resnick; N Raab-Traub
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

9.  Identification of Epstein-Barr nuclear antigen polypeptide in mouse and monkey cells after gene transfer with a cloned 2.9-kilobase-pair subfragment of the genome.

Authors:  D K Fischer; M F Robert; D Shedd; W P Summers; J E Robinson; J Wolak; J E Stefano; G Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

10.  Nucleotide sequence of an mRNA transcribed in latent growth-transforming virus infection indicates that it may encode a membrane protein.

Authors:  S Fennewald; V van Santen; E Kieff
Journal:  J Virol       Date:  1984-08       Impact factor: 5.103
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