Subchronic infusion of clenbuterol, a beta-adrenergic agonist, decreases the cerebellar beta receptor.

Subchronic, peripheral infusion of clenbuterol, a beta-adrenergic agonist, markedly reduced beta receptor density and isoproterenol-sensitive adenylate cyclase activity in the cerebellum of the rat. In contrast, infusion of salbutamol, isoproterenol or desipramine did not alter the beta receptor. The result of clenbuterol administration demonstrates, for the first time, a significant alteration of the cerebellar beta 2 receptor to a pharmacologic manipulation. This alteration may influence physiological and behavioral processes regulated by the cerebellum.