Literature DB >> 4020382

Tolerance to or facilitation of pharmacological effects induced by chronic treatment with the beta-adrenergic stimulant clenbuterol.

H Francès, B Diquet, P Goldschmidt, P Simon.   

Abstract

The effect in mice of chronic administration of the beta-adrenergic agonist clenbuterol was studied using four pharmacological tests, two of which are predictive of antidepressant activity in man. The suppressive effect of acute administration of the beta-adrenergic agonist in two tests unrelated to antidepressant activity, locomotor activity and investigation of food, was attenuated after chronic treatment. However, in the two tests which are predictive of antidepressant activity, antagonism of reserpine induced hypothermia and potentiation of yohimbine toxicity, the effect of clenbuterol was greater following chronic treatment.

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Year:  1985        PMID： 4020382     DOI： 10.1007/bf01260416

Source DB:  PubMed          Journal:  J Neural Transm            Impact factor:   3.575


  34 in total

1.  [USE OF A PARTICULAR MOUSE REACTION (HOLE BOARD METHOD) FOR THE STUDY OF PSYCHOTROPIC DRUGS].

Authors:  J R BOISSIER; P SIMON; J M LWOFF
Journal:  Therapie       Date:  1964 May-Jun       Impact factor: 2.070

2.  Mechanism of isoproterenol-induced desensitization of tracheal smooth muscle.

Authors:  C S Lin; L Hurwitz; J Jenne; B P Avner
Journal:  J Pharmacol Exp Ther       Date:  1977-10       Impact factor: 4.030

3.  Stimulation of beta-adrenergic receptors and spontaneous motor activity in mice.

Authors:  P L Goldschmidt; H Frances; P Simon
Journal:  Pharmacol Biochem Behav       Date:  1984-08       Impact factor: 3.533

4.  Antagonism by d,1-propranolol of imipramine effects in mice.

Authors:  M Souto; H Francès; Y Lecrubier; A J Puech; P Simon
Journal:  Eur J Pharmacol       Date:  1979-11-23       Impact factor: 4.432

5.  Subchronic infusion of clenbuterol, a beta-adrenergic agonist, decreases the cerebellar beta receptor.

Authors:  D J Dooley; K L Hauser
Journal:  Neurosci Lett       Date:  1983-03-28       Impact factor: 3.046

6.  Tachyphylaxis to beta-adrenoceptor agonists in guinea pig airway smooth muscle in vivo and in vitro.

Authors:  J S Douglas; A J Lewis; P Ridgway; C Brink; A Bouhuys
Journal:  Eur J Pharmacol       Date:  1977-04-07       Impact factor: 4.432

7.  Adrenergic and serotonergic receptor binding in rat brain after chronic desmethylimipramine treatment.

Authors:  D A Bergstrom; K J Kellar
Journal:  J Pharmacol Exp Ther       Date:  1979-05       Impact factor: 4.030

8.  The value of the reserpine test in psychopharmacology.

Authors:  M Bourin; M Poncelet; R Chermat; P Simon
Journal:  Arzneimittelforschung       Date:  1983

9.  Evidence that systemically administered salbutamol reduces food intake in rats by acting on central beta-adrenergic sites.

Authors:  F Borsini; C Bendotti; P Thurlby; R Samanin
Journal:  Life Sci       Date:  1982-03-15       Impact factor: 5.037

10.  Beta-adrenoceptor desensitization in rat lung: functional and biochemical aspects.

Authors:  M P Abbracchio; F Cattabeni; E Coen; Y Torres-Hernandez; C Omini
Journal:  Eur J Pharmacol       Date:  1983-04-22       Impact factor: 4.432
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  2 in total

1.  Chronic beta-adrenergic stimulation increases in mice the sensitivity to methysergide and the number of cerebral high affinity serotonin binding sites (5-HT-1).

Authors:  H Frances; C Bulach; P Simon; M Fillion; G Fillion
Journal:  J Neural Transm       Date:  1986       Impact factor: 3.575

2.  Lesions of the serotonergic system impair the facilitation of but not the tolerance to the effects of chronic clenbuterol administration.

Authors:  H Francès; R Raisman; P Simon; I Struck
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530
  2 in total

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