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Literature DB >> 6304001

Comparison of miconazole- and ketoconazole-induced release of K+ from Candida species.

Abstract

Relatively high concentrations of miconazole caused immediate and rapid release of K+ from strains of Candida albicans and Can. parapsilosis. Ketoconazole did not. These results support the recent hypothesis that ketonocazole, unlike related antifungal imidazole-containing drugs, cannot exert a direct membrane damaging effect.

Entities: Chemical Species

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Year: 1983 PMID： 6304001 DOI： 10.1093/jac/11.4.381

Source DB: PubMed Journal: J Antimicrob Chemother ISSN： 0305-7453 Impact factor: 5.790

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Cited

13 in total

Review 1. Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance.

Authors: M A Ghannoum; L B Rice
Journal: Clin Microbiol Rev Date: 1999-10 Impact factor: 26.132

2. Canadian clinical practice guidelines for invasive candidiasis in adults.

Authors: Eric J Bow; Gerald Evans; Jeff Fuller; Michel Laverdière; Coleman Rotstein; Robert Rennie; Stephen D Shafran; Don Sheppard; Sylvie Carle; Peter Phillips; Donald C Vinh
Journal: Can J Infect Dis Med Microbiol Date: 2010 Impact factor: 2.471

3. Direct membrane-damaging effect of ketoconazole and tioconazole on Candida albicans demonstrated by bioluminescent assay of ATP.

Authors: S Anséhn; L Nilsson
Journal: Antimicrob Agents Chemother Date: 1984-07 Impact factor: 5.191

Comparison of miconazole- and ketoconazole-induced release of K+ from Candida species.

Review 1. Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance.

2. Canadian clinical practice guidelines for invasive candidiasis in adults.

3. Direct membrane-damaging effect of ketoconazole and tioconazole on Candida albicans demonstrated by bioluminescent assay of ATP.

4. Is it morphologic type or physiologic state that governs susceptibility of Candida albicans to clotrimazole kill?

5. A new triazole, voriconazole (UK-109,496), blocks sterol biosynthesis in Candida albicans and Candida krusei.

Review 6. Overview of medically important antifungal azole derivatives.

7. Endogenous reactive oxygen species is an important mediator of miconazole antifungal effect.

8. Mechanism of action of efinaconazole, a novel triazole antifungal agent.

9. Growth phase in relation to ketoconazole and miconazole susceptibilities of Candida albicans.

10. Influence of culture medium on susceptibility testing with BAY n 7133 and ketoconazole.