Literature DB >> 6302817

Epstein-Barr virus-specific cytotoxic T cell responses in rheumatoid arthritis patients.

J S Gaston, A B Rickinson, M A Epstein.   

Abstract

The level of Epstein-Barr (EB) virus-specific cytotoxic T cell responsiveness was measured in 21 patients with active, progressive rheumatoid arthritis (RA). A significant number (8 out of 20) of EB virus sero-positive patients showed a markedly impaired responsiveness when compared with a control group of healthy individuals. Serological responses of the RA patients to EB virus antigens were not significantly different from the control group. The defect in EB virus-specific cellular immunity shown by these results is of interest in the light of previous evidence of an alteration in the virus-host balance in RA patients.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 6302817     DOI： 10.1007/bf00286137

Source DB:  PubMed          Journal:  Rheumatol Int        ISSN： 0172-8172            Impact factor:   2.631


  34 in total

1.  Long-term T-cell-mediated immunity to Epstein-Barr virus in man. I. Complete regression of virus-induced transformation in cultures of seropositive donor leukocytes.

Authors:  D J Moss; A B Rickinson; J H Pope
Journal:  Int J Cancer       Date:  1978-12       Impact factor: 7.396

2.  Activation of Epstein-Barr virus by 5-bromodeoxyuridine in "virus-free" human cells (complement-fixing antigen-immunofluorescence-leukocytes).

Authors:  P Gerber
Journal:  Proc Natl Acad Sci U S A       Date:  1972-01       Impact factor: 11.205

3.  Immunofluorescence in cells derived from Burkitt's lymphoma.

Authors:  G Henle; W Henle
Journal:  J Bacteriol       Date:  1966-03       Impact factor: 3.490

4.  Oropharyngeal excretion of Epstein-Barr virus by renal transplant recipients and other patients treated with immunosuppressive drugs.

Authors:  B Strauch; L L Andrews; N Siegel; G Miller
Journal:  Lancet       Date:  1974-02-16       Impact factor: 79.321

5.  Studies on long-term T-cell-mediated immunity to Epstein-BArr virus in immunosuppressed renal allograft recipients.

Authors:  D H Crawford; J M Edwards; P Sweny; A V Hoffbrand; G Janossy
Journal:  Int J Cancer       Date:  1981-12       Impact factor: 7.396

6.  Long-term T-cell-mediated immunity to Epstein-Barr virus in man. III. Activation of cytotoxic T cells in virus-infected leukocyte cultures.

Authors:  D J Moss; A B Rickinson; J H Pope
Journal:  Int J Cancer       Date:  1979-05-15       Impact factor: 7.396

7.  The transformation of adult but not newborn human lymphocytes by Epstein Barr virus and phytohemagglutinin is inhibited by interferon: the early suppression by T cells of Epstein Barr infection is mediated by interferon.

Authors:  D A Thorley-Lawson
Journal:  J Immunol       Date:  1981-03       Impact factor: 5.422

8.  Cytotoxic T cell recognition of Epstein-Barr virus-infected B cells. I. Specificity and HLA restriction of effector cells reactivated in vitro.

Authors:  D J Moss; L E Wallace; A B Rickinson; M A Epstein
Journal:  Eur J Immunol       Date:  1981-09       Impact factor: 5.532

9.  Con A-induced suppressor cell activity and T-lymphocyte subpopulations in peripheral blood lymphocytes of patients with rheumatoid arthritis and juvenile rheumatoid arthritis.

Authors:  J H Dobloug; C Chattopadhyay; O Førre; H M Høyeraal; J B Natvig
Journal:  Scand J Immunol       Date:  1981       Impact factor: 3.487

10.  Suppression of in vitro Epstein-Barr virus infection. A new role for adult human T lymphocytes.

Authors:  D A Thorley-Lawson; L Chess; J L Strominger
Journal:  J Exp Med       Date:  1977-08-01       Impact factor: 14.307
View more
  11 in total

1.  Epstein-Barr virus serologic abnormalities and risk of rheumatoid arthritis among women.

Authors:  Barbara L Goldstein; Lori B Chibnik; Elizabeth W Karlson; Karen H Costenbader
Journal:  Autoimmunity       Date:  2011-10-20       Impact factor: 2.815

Review 2.  The Epstein-Barr virus in autoimmunity.

Authors:  J H Vaughan
Journal:  Springer Semin Immunopathol       Date:  1995

3.  Subsets of T lymphocytes in relation to T lymphocyte function in multiple sclerosis.

Authors:  J C Craig; S A Hawkins; M W Swallow; J A Lyttle; V H Patterson; J D Merrett; M Haire
Journal:  Clin Exp Immunol       Date:  1985-09       Impact factor: 4.330

4.  Cytotoxic mechanisms in vitro against Epstein-Barr virus infected lymphoblastoid cell lines in rheumatoid arthritis.

Authors:  M B McChesney; A D Bankhurst
Journal:  Ann Rheum Dis       Date:  1986-07       Impact factor: 19.103

5.  Disturbance of the Epstein-Barr virus-host balance in rheumatoid arthritis patients: a quantitative study.

Authors:  Q Y Yao; A B Rickinson; J S Gaston; M A Epstein
Journal:  Clin Exp Immunol       Date:  1986-05       Impact factor: 4.330

6.  Epstein-Barr (EB) virus infection in homosexual men in London.

Authors:  D H Crawford; I Weller; V Iliescu; D W Wara
Journal:  Br J Vener Dis       Date:  1984-08

7.  T cell cytotoxicity to Epstein-Barr virus infected B cells: comparison of patients with rheumatoid arthritis and their HLA identical siblings.

Authors:  V R Winrow; J Norton; E J Holborow; H E Stierle; A Young; J A Sachs
Journal:  Ann Rheum Dis       Date:  1988-04       Impact factor: 19.103

8.  Abnormal responses of rheumatoid arthritis lymphocytes to Epstein-Barr virus infection in vitro: evidence for multiple defects.

Authors:  W L Irving; P R Walker; P M Lydyard
Journal:  Ann Rheum Dis       Date:  1985-07       Impact factor: 19.103

9.  The abnormal cytotoxic T cell response to Epstein-Barr virus in rheumatoid arthritis is correlated with disease activity and occurs in other arthropathies.

Authors:  J S Gaston; A B Rickinson; Q Y Yao; M A Epstein
Journal:  Ann Rheum Dis       Date:  1986-11       Impact factor: 19.103

10.  CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis.

Authors:  Michael P Pender
Journal:  Autoimmune Dis       Date:  2012-01-24
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.