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Literature DB >> 6302536

Interaction of naloxone with the opioid receptor complex in vitro.

Abstract

Previous work from this laboratory suggests that distinct morphine and enkephalin receptors coexist in an opioid receptor complex. In this paper the interaction of naloxone with the receptor complex is studied. The results further strengthens the hypothesis that leucine enkephalin binds poorly to the morphine receptor and that morphine and enkephalin receptors are allosterically coupled.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1982 PMID： 6302536 DOI： 10.1007/bf00966066

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

18 in total

1. Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity.

Authors: K J Chang; P Cuatrecasas
Journal: J Biol Chem Date: 1979-04-25 Impact factor: 5.157

2. Characterization of opioid receptors in nervous tissue.

Authors: H W Kosterlitz; S J Paterson
Journal: Proc R Soc Lond B Biol Sci Date: 1980-10-29

3. Mathematical theory of complex ligand-binding systems of equilibrium: some methods for parameter fitting.

Authors: H A Feldman
Journal: Anal Biochem Date: 1972-08 Impact factor: 3.365

4. Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography.

Authors: R R Goodman; S H Snyder; M J Kuhar; W S Young
Journal: Proc Natl Acad Sci U S A Date: 1980-10 Impact factor: 11.205

5. Morphine allosterically modulates the binding of [3H]leucine enkephalin to a particulate fraction of rat brain.

Authors: R B Rothman; T C Westfall
Journal: Mol Pharmacol Date: 1982-05 Impact factor: 4.436

6. Allosteric coupling between morphine and enkephalin receptors in vitro.

Authors: R B Rothman; T C Westfall
Journal: Mol Pharmacol Date: 1982-05 Impact factor: 4.436

7. Specific protection of the binding sites of D-Ala2-D-Leu5-enkephalin (delta-receptors) and dihydromorphine (mu-receptors).

Authors: L E Robson; H W Kosterlitz
Journal: Proc R Soc Lond B Biol Sci Date: 1979-08-31

Interaction of naloxone with the opioid receptor complex in vitro.

1. Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity.

2. Characterization of opioid receptors in nervous tissue.

3. Mathematical theory of complex ligand-binding systems of equilibrium: some methods for parameter fitting.

4. Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography.

5. Morphine allosterically modulates the binding of [3H]leucine enkephalin to a particulate fraction of rat brain.

6. Allosteric coupling between morphine and enkephalin receptors in vitro.

7. Specific protection of the binding sites of D-Ala2-D-Leu5-enkephalin (delta-receptors) and dihydromorphine (mu-receptors).

8. 3H-Leu5-enkephalin specific binding to synaptic membrane-comparison with 3H-dihydromorphine and 3H-naloxone.

9. Characterization of the kappa-subtype of the opiate receptor in the guinea-pig brain.

10. Allosteric modulation by leucine-enkephalin of [3H]naloxone binding in rat brain.

1. Multiple opioid receptors: an examination of the dissociation of [3H]leucine enkephalin from rat brain membranes.

2. Interaction of leucine enkephalin with (3H)naloxone binding in rat brain: evidence for an opioid receptor complex.