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Literature DB >> 6268425

Allosteric modulation by leucine-enkephalin of [3H]naloxone binding in rat brain.

Abstract

The interaction of morphine and leucine-enkephalin with the binding site labeled by [3H]naloxone in the presence of sodium was compared. The effect of fixed concentrations of morphine and leucine enkephalin on the saturation binding of [3H]naloxone demonstrated that whereas morphine was a competitive inhibitor, leucine enkephalin caused a dose-dependent masking of binding sites. From these data we conclude that the enkephalin receptor is allosterically coupled to the morphine receptor.

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Year: 1981 PMID： 6268425 DOI： 10.1016/0014-2999(81)90577-x

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

12 in total

1. Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.

Authors: I Gomes; B A Jordan; A Gupta; N Trapaidze; V Nagy; L A Devi
Journal: J Neurosci Date: 2000-11-15 Impact factor: 6.167

2. A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia.

Authors: Ivone Gomes; Achla Gupta; Julija Filipovska; Hazel H Szeto; John E Pintar; Lakshmi A Devi
Journal: Proc Natl Acad Sci U S A Date: 2004-03-24 Impact factor: 11.205

3. Opiate receptors and the endorphin-mediated cardiovascular effects of clonidine in rats: evidence for hypertension-induced mu-subtype to delta-subtype changes.

Authors: R Mosqueda-Garcia; G Kunos
Journal: Proc Natl Acad Sci U S A Date: 1987-12 Impact factor: 11.205

4. Detailed analysis of heterogeneity of [3H]naloxone binding sites in rat brain synaptosomes.

Authors: M Szücs; A Borsodi; A Bogdány; J Gaál; J Batke; G Tóth
Journal: Neurochem Res Date: 1987-07 Impact factor: 3.996

5. The excitatory response of in vitro hippocampal pyramidal cells to normorphine and methionine-enkephalin may be mediated by different receptor populations.

Authors: E D French; W Zieglgänsberger
Journal: Exp Brain Res Date: 1982 Impact factor: 1.972

Allosteric modulation by leucine-enkephalin of [3H]naloxone binding in rat brain.

1. Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.

2. A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia.

3. Opiate receptors and the endorphin-mediated cardiovascular effects of clonidine in rats: evidence for hypertension-induced mu-subtype to delta-subtype changes.

4. Detailed analysis of heterogeneity of [3H]naloxone binding sites in rat brain synaptosomes.

5. The excitatory response of in vitro hippocampal pyramidal cells to normorphine and methionine-enkephalin may be mediated by different receptor populations.

6. Interaction of naloxone with the opioid receptor complex in vitro.

7. Multiple opioid receptors: an examination of the dissociation of [3H]leucine enkephalin from rat brain membranes.

8. Opioid-induced respiratory depression and analgesia may be mediated by different subreceptors.

9. Interaction of leucine enkephalin with (3H)naloxone binding in rat brain: evidence for an opioid receptor complex.

Review 10. Peripheral beta-endorphin and pain modulation.