Literature DB >> 6301850

The picrotoxin-like action of a convulsant benzodiazepine, Ro5-3663.

N L Harrison, M A Simmonds.   

Abstract

The potency and site of action of Ro5-3663 as a GABA antagonist were investigated in the rat cuneate slice in vitro. A Schild plot for Ro5-3663 was clearly non-linear but enabled a pA2 value of 3.97 to be calculated. Combination studies using the 'classical' GABA antagonists bicuculline and picrotoxin indicated that Ro5-3663 acted at a separate site from bicuculline, but may share a common site with picrotoxin.

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Year:  1983        PMID： 6301850     DOI： 10.1016/0014-2999(83)90064-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  4 in total

1.  Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants.

Authors:  R G Lister; D J Nutt
Journal:  Br J Pharmacol       Date:  1988-01       Impact factor: 8.739

Review 2.  Multiple sites of action for anxiogenic drugs: behavioural, electrophysiological and biochemical correlations.

Authors:  S Pellow; S E File
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

3.  GABAergic modulation of inferior colliculus excitability: role in the ethanol withdrawal audiogenic seizures.

Authors:  G D Frye; T J McCown; G R Breese; S L Peterson
Journal:  J Pharmacol Exp Ther       Date:  1986-05       Impact factor: 4.030

4.  Protection against ethanol-induced gastric damage by drugs acting at the GABA-benzodiazepine receptor complex.

Authors:  R A Najim; K H Karim
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530
  4 in total

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