Literature DB >> 6300652

Oxidation of p-aminophenol catalyzed by horseradish peroxidase and prostaglandin synthase.

P D Josephy, T E Eling, R P Mason.   

Abstract

p-Aminophenol oxidation is catalyzed by horseradish peroxidase. ESR spectroscopy demonstrates the formation of the p-aminophenoxy free radical, the one-electron oxidation product of p-aminophenol. The same radical is formed by alkaline autoxidation of this compound. The ultimate products of p-aminophenol oxidation are mainly polymeric; however, indophenol was isolated in low yield. Oxidation of p-aminophenol is also catalyzed by the hydroperoxidase activity of prostaglandin synthase, using ram seminal microsomal preparations as the enzyme source.

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Year:  1983        PMID： 6300652

Source DB:  PubMed          Journal:  Mol Pharmacol        ISSN： 0026-895X            Impact factor:   4.436


  12 in total

1.  Oxidation of suitable drugs by horseradish peroxidase/hydrogen peroxide results in the oxygenation of arachidonic acid to form hydroperoxyeicosatetraenoic acids in a reverse co-oxidation process.

Authors:  J Baumann; I Just; G Wurm
Journal:  Agents Actions       Date:  1986-01

2.  Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in the Fischer 344 rat.

Authors:  K P Gartland; C T Eason; F W Bonner; J K Nicholson
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

3.  Superoxide dismutase enhances the formation of hydroxyl radicals in the reaction of 3-hydroxyanthranilic acid with molecular oxygen.

Authors:  H Iwahashi; T Ishii; R Sugata; R Kido
Journal:  Biochem J       Date:  1988-05-01       Impact factor: 3.857

4.  Effect of ascorbic acid, acivicin and probenecid on the nephrotoxicity of 4-aminophenol in the Fischer 344 rat.

Authors:  L M Fowler; J R Foster; E A Lock
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153

5.  Continuous treatment of the insensitive munitions compound N-methyl-p-nitro aniline (MNA) in an upflow anaerobic sludge blanket (UASB) bioreactor.

Authors:  Christopher I Olivares; Junqin Wang; Carlos D Silva Luna; Jim A Field; Leif Abrell; Reyes Sierra-Alvarez
Journal:  Chemosphere       Date:  2015-10-23       Impact factor: 7.086

6.  Contribution of reactive oxygen species to para-aminophenol toxicity in LLC-PK1 cells.

Authors:  Brooke D Foreman; Joan B Tarloff
Journal:  Toxicol Appl Pharmacol       Date:  2008-03-04       Impact factor: 4.219

7.  Studies on the effects of L(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) on 4-aminophenol-induced nephrotoxicity in the Fischer 344 rat.

Authors:  M L Anthony; C R Beddell; J C Lindon; J K Nicholson
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153

8.  Nephrotoxicity of 4-amino-3-S-glutathionylphenol and its modulation by metabolism or transport inhibitors.

Authors:  L M Fowler; J R Foster; E A Lock
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

9.  Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety.

Authors:  Bojana Mirković; Izidor Sosič; Stanislav Gobec; Janko Kos
Journal:  PLoS One       Date:  2011-11-04       Impact factor: 3.240

10.  Role of radical cations in aromatic hydrocarbon carcinogenesis.

Authors:  E Cavalieri; E Rogan
Journal:  Environ Health Perspect       Date:  1985-12       Impact factor: 9.031
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